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BioMed Research International
Volume 2015, Article ID 708289, 9 pages
http://dx.doi.org/10.1155/2015/708289
Research Article

Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity

1Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, 13001 E. 17th Place, Box B119, Aurora, CO 80045, USA
2Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, 13001 E. 17th Place, Box B119, Aurora, CO 80045, USA
3Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct., Aurora, CO 80045, USA

Received 4 August 2014; Revised 7 October 2014; Accepted 18 October 2014

Academic Editor: Mikael Knip

Copyright © 2015 Brittni N. Frederiksen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Karvonen, “Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999,” Diabetic Medicine, vol. 23, no. 8, pp. 857–866, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Onkamo, S. Vaananen, M. Karvonen, and J. Tuomilehto, “Worldwide increase in incidence of type I diabetes—the analysis of the data on published incidence trends,” Diabetologia, vol. 42, no. 12, pp. 1395–1403, 1999. View at Google Scholar
  3. C. C. Patterson, G. G. Dahlquist, E. Gyürüs, A. Green, and G. Soltész, “Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study,” The Lancet, vol. 373, no. 9680, pp. 2027–2033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Dabelea, “The accelerating epidemic of childhood diabetes,” The Lancet, vol. 373, no. 9680, pp. 1999–2000, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A.-G. Ziegler and G. T. Nepom, “Prediction and pathogenesis in type 1 diabetes,” Immunity, vol. 32, no. 4, pp. 468–478, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Caillat-Zucman, H.-J. Garchon, J. Timsit et al., “Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus,” The Journal of Clinical Investigation, vol. 90, no. 6, pp. 2242–2250, 1992. View at Publisher · View at Google Scholar · View at Scopus
  7. J. P. H. Shield, E. J. K. Wadsworth, and J. D. Baum, “The genetic contribution to disease pathogenesis in childhood diabetes is greatest in the very young,” Diabetic Medicine, vol. 12, no. 5, pp. 377–379, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. A. K. Steck, T. K. Armstrong, S. R. Babu, and G. S. Eisenbarth, “Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years,” Diabetes, vol. 60, no. 3, pp. 1045–1049, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Petrone, A. Galgani, M. Spoletini et al., “Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype,” Diabetes/Metabolism Research and Reviews, vol. 21, no. 3, pp. 271–275, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. K. M. Gillespie, E. A. M. Gale, and P. J. Bingley, “High familial risk and genetic susceptibility in early onset childhood diabetes,” Diabetes, vol. 51, no. 1, pp. 210–214, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Zevaco-Mattei, D. Reviron, C. Atlan-Gepner et al., “Relationship between HLA-DQ and -DR genotypes and clinical characteristics in a French population of Type 1 diabetic patients,” Diabetic Medicine, vol. 16, no. 3, pp. 201–206, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Cerna, P. Novota, K. Kolostova et al., “HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes,” European Journal of Immunogenetics, vol. 30, no. 6, pp. 401–407, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Pflueger, T. Seppänen-Laakso, T. Suortti et al., “Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes,” Diabetes, vol. 60, no. 11, pp. 2740–2747, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. M. Virtanen, H.-M. Takkinen, J. Nevalainen et al., “Early introduction of root vegetables in infancy associated with advanced ß-cell autoimmunity in young children with human leukocyte antigen-conferred susceptibility to Type 1 diabetes,” Diabetic Medicine, vol. 28, no. 8, pp. 965–971, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Y. Lin, L. J. Wei, and Z. Ying, “Checking the Cox model with cumulative sums of martingale-based residuals,” Biometrika, vol. 80, no. 3, pp. 557–572, 1993. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  16. P. M. Grambsch and T. M. Therneau, “Proportional hazards tests and diagnostics based on weighted residuals,” Biometrika, vol. 81, no. 3, pp. 515–526, 1994. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus
  17. K. R. Hess, “Assessing time-by-covariate interactions in proportional hazards regression models using cubic spline functions,” Statistics in Medicine, vol. 13, no. 10, pp. 1045–1062, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Heinzl and A. Kaider, “Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions,” Computer Methods and Programs in Biomedicine, vol. 54, no. 3, pp. 201–208, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. J. L. Davies, Y. Kawaguchl, S. T. Bennett et al., “A genome-wide search for human type 1 diabetes susceptibility genes,” Nature, vol. 371, no. 6493, pp. 130–136, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. A. P. Lambert, K. M. Gillespie, G. Thomson et al., “Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 8, pp. 4037–4043, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. J. M. Norris, X. Yin, M. M. Lamb et al., “Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes,” The Journal of the American Medical Association, vol. 298, no. 12, pp. 1420–1428, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Norris, M. Kroehl, T. E. Fingerlin et al., “Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young,” Diabetologia, vol. 57, no. 2, pp. 295–304, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. E. G. Bligh and W. J. Dyer, “A rapid method of total lipid extraction and purification,” Canadian Journal of Biochemistry and Physiology, vol. 37, no. 8, pp. 911–917, 1959. View at Publisher · View at Google Scholar · View at Scopus
  24. R. J. Maxwell and W. N. Marmer, “Systematic protocol for the accumulation of fatty acid data from multiple tissue samples: tissue handling, lipid extraction and class separation, and capillary gas chromatographic analysis,” Lipids, vol. 18, no. 7, pp. 453–459, 1983. View at Publisher · View at Google Scholar · View at Scopus
  25. C. E. Grubin, T. Daniels, B. Toivola et al., “A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM,” Diabetologia, vol. 37, no. 4, pp. 344–350, 1994. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Gianani, D. U. Rabin, C. F. Verge et al., “ICA512 autoantibody radioassay,” Diabetes, vol. 44, no. 11, pp. 1340–1344, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Yu, D. T. Robles, N. Abiru et al., “Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 4, pp. 1701–1706, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. R by Meinhard Ploner and Fortran by Georg Heinze, “coxphf: Cox regression with Firth’s penalized likelihood,” 2012, http://cran.r-project.org/web/packages/coxphf/index.html.
  29. R Core Team, R: A Language and Environment for Statistical Computing, 2012, http://www.R-project.org/.
  30. D. Spiegelman, E. Hertzmark, and H. C. Wand, “Point and interval estimates of partial population attributable risks in cohort studies: examples and software,” Cancer Causes and Control, vol. 18, no. 5, pp. 571–579, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Hertzmark, H. Wand, and D. Spiegelman, “The SAS PAR Macro,” 2012.
  32. M. A. Laaksonen, E. Virtala, P. Knekt, H. Oja, and T. Härkänen, “SAS macros for calculation of population attributable fraction in a cohort study design,” Journal of Statistical Software, vol. 43, no. 7, pp. 1–25, 2011. View at Google Scholar · View at Scopus
  33. L. M. Ide, K. J. Barriga, G. S. Eisenbarth, J. M. Norris, and M. Rewers, “Heterogeneity of islet autoimmunity developing in children 0–12 years old [abstract],” Diabetes, vol. 60, supplement 1, p. A43, 2011. View at Google Scholar
  34. J. N. Kostraba, K. J. Cruickshanks, T. G. Neville et al., “Clinical characteristics of IDDM in Hispanics and non-Hispanic whites: little evidence of heterogeneity by ethnicity,” Diabetes Care, vol. 15, no. 10, pp. 1303–1309, 1992. View at Publisher · View at Google Scholar · View at Scopus
  35. E. A. M. Gale, “Maternal age and diabetes in childhood,” The British Medical Journal, vol. 340, no. 7744, article c623, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. L. C. Stene, K. Barriga, J. M. Norris et al., “Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the young,” American Journal of Epidemiology, vol. 160, no. 1, pp. 3–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Frederiksen, M. Kroehl, M. M. Lamb et al., “Infant exposures and development of type 1 diabetes mellitus: the Diabetes Autoimmunity Study in the Young (DAISY),” JAMA Pediatrics, vol. 167, no. 9, pp. 808–815, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. C. R. Cardwell, L. C. Stene, G. Joner et al., “Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies,” Diabetologia, vol. 51, no. 5, pp. 726–735, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. J. M. Norris, K. Barriga, G. Klingensmith et al., “Timing of initial cereal exposure in infancy and risk of islet autoimmunity,” Journal of the American Medical Association, vol. 290, no. 13, pp. 1713–1720, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. L. C. Stene and E. A. M. Gale, “The prenatal environment and type 1 diabetes,” Diabetologia, vol. 56, no. 9, pp. 1888–1897, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. R. M. Leech, S. A. McNaughton, and A. Timperio, “Clustering of children's obesity-related behaviours: associations with sociodemographic indicators,” European Journal of Clinical Nutrition, vol. 68, no. 5, pp. 623–628, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. T. M. Therneau and P. M. Grambsch, Modeling Survival Data: Extending the Cox Model, Statistics for Biology and Health, Springer, New York, NY, USA, 2000. View at Publisher · View at Google Scholar · View at MathSciNet
  43. B. N. Frederiksen, A. K. Steck, M. Kroehl et al., “Evidence of stage- and age-related heterogeneity of Non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young,” Clinical and Developmental Immunology, vol. 2013, Article ID 417657, 8 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus