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BioMed Research International
Volume 2015 (2015), Article ID 712020, 6 pages
Research Article

Levels of Anti-HBs Antibody in HBV-Vaccinated Students Enrolled in the Faculty of Medicine, Dentistry and Health Professions of a Large Italian University

1Center of Occupational Medicine, Sapienza University of Rome, 5-00185 Rome, Italy
2Department of Public Health and Infectious Diseases, Sapienza University of Rome, 5-00185 Rome, Italy
3Eleonora Lorillard Spencer-Cenci Foundation, 00185 Rome, Italy

Received 24 February 2014; Revised 28 May 2014; Accepted 16 June 2014

Academic Editor: Haruki Komatsu

Copyright © 2015 Sabina Sernia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Prophylaxis against hepatitis B virus (HBV) addressed to students of the faculties of health professions has received great attention. Objectives. The present study aims to assess vaccination coverage against hepatitis B in healthcare professionals in training. Materials and Methods. A retrospective study was carried out using data from the students of medicine, dentistry, and health professions. Results. 4180 vaccination certifications were examined through the internal database. Significant differences (<0.0001) emerge between the number of doses applied and the antibody level. 50.4% of the students have nonprotective antibody levels (<10 IU). The age of the first dose significantly influences the level of coverage, resulting in more coverage in those vaccinated with earlier onset (1–10 years). Antibody levels are not significantly different by type of course; the levels of noncoverage are present in 44.4% of the students of medicine and dentistry and in 50.6% among those belonging to the health professions. Conclusions. This study represents one of the first experiences in Italy on vaccination against HBV and the relationship between doses of vaccination and antibody titer in the biomedical students that can configure a step forward in the real-time monitoring in order to establish a register of vaccination.