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BioMed Research International
Volume 2015, Article ID 712438, 9 pages
http://dx.doi.org/10.1155/2015/712438
Research Article

Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival

1Laboratory of Gene Expression, Molecular Diagnosis and Modern Therapeutics, Department of Molecular Biology and Genetics, Faculty of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece
2Division of Genome and Gene Expression Data Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138671
3Department of Oncology, University Hospital of Lausanne (CHUV), Ludwig Cancer Research Center, University of Lausanne, 1011 Lausanne, Switzerland
4Laboratory of Histology and Embryology, School of Medicine, Faculty of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece
5Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA 19014, USA
6Department of Clinical Oncology, School of Medicine, Faculty of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece
7Medical Statistics Lab, School of Medicine, Faculty of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece

Received 12 January 2015; Revised 27 May 2015; Accepted 28 May 2015

Academic Editor: Beric Henderson

Copyright © 2015 Athanasios Karapetsas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure S1: Kaplan-Meier curve analysis suggest a trend towards higher overall survival for patients with high mRNA levels of GPC6 or TMEM132D. Kaplan-Meier overall survival curves calculated for GPC6 (A) and TMEM132D (B) tumoral mRNA levels in 35 early stage ovarian cancer patients. The patients were divided into two groups based on their GPC6 mRNA levels (A, cut-off point: 1.8 relative expression units) or their TMEM132D mRNA levels (B, cut-off point: 5.0 relative expression units).

Supplemental Table S1: Association of GPC6 mRNA level with the stage, grade and histotype of the 35 early stage tumors.

Supplemental Table S2: Association of TMEM132D mRNA level with the stage, grade and histotype of the 35 early stage tumors.

  1. Supplementary Material