Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for BioMed Research International, enter your email address in the box below.

BioMed Research International
Volume 2015 (2015), Article ID 715752, 10 pages
http://dx.doi.org/10.1155/2015/715752
Research Article

Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Janne Koskimäki,1,2 Miikka Tarkia,3 Tuula Ahtola-Sätilä,4 Lasse Saloranta,4 Outi Simola,4 Ari-Pekka Forsback,5 Aki Laakso,2 and Janek Frantzén6

1Faculty of Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, 20520 Turku, Finland
2Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, Topeliuksenkatu 5, 00029 Helsinki, Finland
3Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20521 Turku, Finland
4Chemistry and Safety Sciences, R&D, Orion Corporation, Orion Pharma, P.O. Box 65, Orionintie 1A, 02101 Espoo, Finland
5Delsitech Ltd., Itäinen Pitkäkatu 4B, 20520 Turku, Finland
6Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, P.O. Box 52, Hämeentie 11, 20521 Turku, Finland

Received 26 August 2014; Accepted 10 October 2014

Academic Editor: Kuo-Sheng Hung

Copyright © 2015 Janne Koskimäki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Laursen, F. Jensen, E. Mikkelsen, and P. Jakobsen, “Nimodipine treatment of subarachnoid hemorrhage,” Clinical Neurology and Neurosurgery, vol. 90, no. 4, pp. 329–337, 1988. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Pickard, G. D. Murray, R. Illingworth et al., “Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial,” The British Medical Journal, vol. 298, no. 6674, pp. 636–642, 1989. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Pluta, J. Hansen-Schwartz, J. Dreier et al., “Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought,” Neurological Research, vol. 31, no. 2, pp. 151–158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. K. Athar and J. M. Levine, “Treatment options for cerebral vasospasm in aneurysmal subarachnoid hemorrhage,” Neurotherapeutics, vol. 9, no. 1, pp. 37–43, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Barry, R. J. Turner, F. Corrigan, and R. Vink, “New therapeutic approaches to subarachnoid hemorrhage,” Expert Opinion on Investigational Drugs, vol. 21, no. 6, pp. 845–859, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Caner, J. Hou, O. Altay, M. Fuj II, and J. H. Zhang, “Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage,” Journal of Neurochemistry, vol. 123, supplement 2, pp. 12–21, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. F. A. Sehba, J. Hou, R. M. Pluta, and J. H. Zhang, “The importance of early brain injury after subarachnoid hemorrhage,” Progress in Neurobiology, vol. 97, no. 1, pp. 14–37, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Barth, H.-H. Capelle, S. Weidauer et al., “Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study,” Stroke, vol. 38, no. 2, pp. 330–336, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. V. A. H. Sillberg, G. A. Wells, and J. J. Perry, “Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis,” Stroke, vol. 39, no. 9, pp. 2622–2626, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Jain, G. P. Rath, H. H. Dash, P. K. Bithal, R. S. Chouhan, and A. Suri, “Stellate ganglion block for treatment of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage—a preliminary study,” Journal of Anaesthesiology Clinical Pharmacology, vol. 27, no. 4, pp. 516–521, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Takahashi, Z.-D. Zhang, and R. L. Macdonald, “Sphenopalatine ganglion stimulation for vasospasm after experimental subarachnoid hemorrhage: laboratory investigationge: laboratory investigation,” Journal of Neurosurgery, vol. 114, no. 4, pp. 1104–1109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Senbokuya, H. Kinouchi, K. Kanemaru et al., “Effects of cilostazol on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a multicenter prospective, randomized, open-label blinded end point trial,” Journal of Neurosurgery, vol. 118, no. 1, pp. 121–130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. G. J. Velat, M. M. Kimball, J. D. Mocco, and B. L. Hoh, “Vasospasm after aneurysmal subarachnoid hemorrhage: review of randomized controlled trials and meta-analyses in the literature,” World Neurosurgery, vol. 76, no. 5, pp. 446–454, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. P. Zhang, L. B. E. Shields, T. L. Yao, S. R. Dashti, and C. B. Shields, “Intrathecal treatment of cerebral vasospasm,” Journal of Stroke and Cerebrovascular Diseases, vol. 22, no. 8, pp. 1201–1211, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. D. J. Cook, S. Kan, J. Ai, H. Kasuya, and R. L. Macdonald, “Cisternal sustained release dihydropyridines for subarachnoid hemorrhage,” Current Neurovascular Research, vol. 9, no. 2, pp. 139–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Barth, P. Pena, M. Seiz et al., “Feasibility of intraventricular nicardipine prolonged release implants in patients following aneurysmal subarachnoid haemorrhage,” British Journal of Neurosurgery, vol. 25, no. 6, pp. 677–683, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Hänggi, B. Turowski, K. Beseoglu, M. Yong, and H. J. Steiger, “Intra-arterial nimodipine for severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage: influence on clinical course and cerebral perfusion,” American Journal of Neuroradiology, vol. 29, no. 6, pp. 1053–1060, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Hänggi, K. Beseoglu, B. Turowski, and H.-J. Steiger, “Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy,” Clinical Neurology and Neurosurgery, vol. 110, no. 8, pp. 784–790, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. D. I. Vergouwen, N. Etminan, D. Ilodigwe, and R. L. MacDonald, “Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage,” Journal of Cerebral Blood Flow and Metabolism, vol. 31, no. 7, pp. 1545–1553, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. I. Vergouwen, M. Vermeulen, B. A. Coert, E. S. G. Stroes, and Y. B. W. E. M. Roos, “Microthrombosis after aneurysmal subarachnoid hemorrhage: an additional explanation for delayed cerebral ischemia,” Journal of Cerebral Blood Flow & Metabolism, vol. 28, no. 11, pp. 1761–1770, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. S. M. Dorhout Mees, G. J. Rinkel, V. L. Feigin et al., “Calcium antagonists for aneurysmal subarachnoid haemorrhage,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD000277, 2007. View at Google Scholar · View at Scopus
  22. J. P. Dreier, O. Windmüller, G. Petzold et al., “Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats,” Neurosurgery, vol. 51, no. 6, pp. 1457–1467, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Bege, T. Renette, T. Endres, M. Beck-Broichsitter, D. Hänggi, and T. Kissel, “In situ forming nimodipine depot system based on microparticles for the treatment of posthemorrhagic cerebral vasospasm,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 84, no. 1, pp. 99–105, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. A. K. Mehta, K. S. Yadav, and K. K. Sawant, “Nimodipine loaded PLGA nanoparticles: formulation optimization using factorial design, characterization and in vitro evaluation,” Current Drug Delivery, vol. 4, no. 3, pp. 185–193, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Hänggi, J. Perrin, S. Eicker et al., “Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage,” PLoS ONE, vol. 7, no. 9, Article ID e42597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Hänggi, S. Eicker, K. Beseoglu et al., “Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model,” Neurosurgery, vol. 64, no. 6, pp. 1155–1159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Woitzik, J. P. Dreier, N. Hecht et al., “Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage,” Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 2, pp. 203–212, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Kawashima, H. Kasuya, A. Sasahara, M. Miyajima, M. Izawa, and T. Hori, “Prevention of cerebral vasospasm by nicardipine prolonged-release implants in dogs,” Neurological Research, vol. 22, no. 6, pp. 634–641, 2000. View at Google Scholar · View at Scopus
  29. H. Kasuya, H. Onda, A. Sasahara, M. Takeshita, and T. Hori, “Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage,” Neurosurgery, vol. 56, no. 5, pp. 895–901, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. R. L. Macdonald, M. Leung, and T. Tice, “Intracranial drug delivery for subarachnoid hemorrhage,” Therapeutic Delivery, vol. 3, no. 1, pp. 91–103, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Simovic, N. Ghouchi-Eskandar, A. M. Sinn, D. Losic, and C. A. Prestidge, “Silica materials in drug delivery applications,” Current Drug Discovery Technologies, vol. 8, no. 3, pp. 269–276, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Yang, S. Gai, and J. Lin, “Functionalized mesoporous silica materials for controlled drug delivery,” Chemical Society Reviews, vol. 41, no. 9, pp. 3679–3698, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Quintanar-Guerrero, A. Ganem-Quintanar, M. G. Nava-Arzaluz, and E. Piñón-Segundo, “Silica xerogels as pharmaceutical drug carriers,” Expert Opinion on Drug Delivery, vol. 6, no. 5, pp. 485–498, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Kortesuo, M. Ahola, M. Kangas, A. Yli-Urpo, J. Kiesvaara, and M. Marvola, “In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters,” International Journal of Pharmaceutics, vol. 221, no. 1-2, pp. 107–114, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. O. G. Koch and G. A. Koch-Dedic, Handbuch der Spureanalyse, Springer, Berlin, Germany, 1974.