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BioMed Research International
Volume 2015, Article ID 715752, 10 pages
http://dx.doi.org/10.1155/2015/715752
Research Article

Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Janne Koskimäki,1,2 Miikka Tarkia,3 Tuula Ahtola-Sätilä,4 Lasse Saloranta,4 Outi Simola,4 Ari-Pekka Forsback,5 Aki Laakso,2 and Janek Frantzén6

1Faculty of Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, 20520 Turku, Finland
2Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, Topeliuksenkatu 5, 00029 Helsinki, Finland
3Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20521 Turku, Finland
4Chemistry and Safety Sciences, R&D, Orion Corporation, Orion Pharma, P.O. Box 65, Orionintie 1A, 02101 Espoo, Finland
5Delsitech Ltd., Itäinen Pitkäkatu 4B, 20520 Turku, Finland
6Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, P.O. Box 52, Hämeentie 11, 20521 Turku, Finland

Received 26 August 2014; Accepted 10 October 2014

Academic Editor: Kuo-Sheng Hung

Copyright © 2015 Janne Koskimäki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

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