Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Table 2

Allocation of treatment groups and schedule of the dog study.

Group	Procedure	Parenchyma implant	Animals per group	Animal IDs
Active 1	Nimodipine implant 8.5 mg × 5 (total 42.5 mg)	NA	3	1, 2, 3
Active 2	Nimodipine implant 8.5 mg × 1	NA	3	4, 5, 6
Sham	Sham operation	NA	3	7, 8, 9
Samples	Day 1	Day 5	Day 7	Day 14	Day 21
Plasma (vena jugularis)	1 h, 1.5 h, 2.5 h, 4 h, 6 h, and 22 h (on day 2)	x	x	x	x
Cerebrospinal fluid	1 h		x	x	x
CT			x	x	x

NA = not applicable.