Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Table 5

Concentrations of nimodipine at different time points after surgery in dogs and pigs (ng/mL).

	1 h		Day 7		Day 14		Day 21
	Jugularis	CSF	Jugularis	CSF	Jugularis	CSF	Jugularis	CSF
Nimodipine 8.5 mg implant in dogs	17.79 ± 15.17	2.19 ± 1.90	6.13 ± 4.66	0.025 ± 0.009	11.51 ± 3.77	0.030 ± 0.008	3.05 ± 1.53	0.013 ± 0.004
Nimodipine 5 × 8.5 mg implant in dogs	63.9 ± 18.7	0.110 ± 0.005	37.8 ± 15.8	0.095 ± 0.008	36.5 ± 9.97	0.083 ± 0.009	32.9 ± 8.77	0.034 ± 0.004
	Day 5				Day 7
	Jugularis		Ear	CSF	Jugularis	Ear		CSF
Nimodipine 5 mg implant in pigs	0.045 ± 0.008		0.027 ± 0.005	0.027 ± 0.022	0.054 ± 0.006	0.045 ± 0.020		0.038 ± 0.017