BioMed Research International / 2015 / Article / Tab 1

Research Article

Redesigning Protein Cavities as a Strategy for Increasing Affinity in Protein-Protein Interaction: Interferon-γ Receptor 1 as a Model

Table 1

Cavities in the four molecules of the IFNγR1 receptor in crystal structures 1fg9 [19] and 1fyh [20]. The receptor molecules are labeled by chain ID (chains C and D from 1fg9 and chains B and E from 1fyh). Figure 2 shows cavities 1–8 as they project into the chain C of 1fg9.

Surface [Å2]*Number of residues lining the cavityResidues selected for mutationCavity observed in IFNγR1 chain of

11347V35, A114 C D
21335B E
347014D124C D
42629H222C DB E
51206C DE
61657C DE
71777DB E

Surface calculated with a probe radius of 0.25 Å for cavities combined from all relevant receptor chains.
Some residues are shared by neighboring cavities.

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