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BioMed Research International
Volume 2015, Article ID 717509, 12 pages
http://dx.doi.org/10.1155/2015/717509
Review Article

Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas

1Laboratory of Research in Experimental Pathology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico
2Laboratory of Psicoacoustics and Auditivy Physiology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico

Received 6 June 2014; Revised 16 November 2014; Accepted 16 November 2014

Academic Editor: Elisa Giovannetti

Copyright © 2015 Sebastian López-Ochoa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression. In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others. In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered. Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them. An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum. miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins. In this review some miRNAs are considered to be important in MB studies. Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634. Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor. In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.