Table 4: Regions showing significant differences in VMHC between patients and healthy controls.

Brain regionsMNI coordinates , , (mm)Peak scoreVoxels

Decreased in T2DM patients
Middle temporal gyrus±54, −45, 6 −4.8383289
Middle frontal gyrus±45, 45, 24−2.0195100
Superior frontal gyrus ±15, 9, 57−5.1613267
Inferior parietal lobule±63, −27, 21−4.384297
Anterior cingulate gyrus±6, 24, 21−3.830991

Increased in T2DM patients
Inferior osccipital gyrus ±36, −72, −94.7328199
Precentral gyrus±36, −27, 633.2897234

A corrected threshold of determined by Monte Carlo simulation was taken as meaning that there was a significant difference between groups. MNI: Montreal Neurological Institute; cluster size is in mm3.