Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study

Table 4

Regions showing significant differences in VMHC between patients and healthy controls.

Brain regions	MNI coordinates , , (mm)	Peak score	Voxels
Decreased in T2DM patients
Middle temporal gyrus	±54, −45, 6	−4.8383	289
Middle frontal gyrus	±45, 45, 24	−2.0195	100
Superior frontal gyrus	±15, 9, 57	−5.1613	267
Inferior parietal lobule	±63, −27, 21	−4.3842	97
Anterior cingulate gyrus	±6, 24, 21	−3.8309	91
Increased in T2DM patients
Inferior osccipital gyrus	±36, −72, −9	4.7328	199
Precentral gyrus	±36, −27, 63	3.2897	234

A corrected threshold of determined by Monte Carlo simulation was taken as meaning that there was a significant difference between groups. MNI: Montreal Neurological Institute; cluster size is in mm³.