Research Article
Retrospective Analysis of Bevacizumab in Combination with Fotemustine in Chinese Patients with Recurrent Glioblastoma Multiforme
Table 3
Univariate and multivariate analysis of prognostic factors for overall survival in 176 patients with recurrent glioblastoma multiforme.
| | Univariate effect | Multivariate effect | HR | 95% CI | | HR | 95% CI | |
| Gender | | | | | | | Female | 1 | | | 1 | | | Male | 0.97 | (0.71–1.56) | 0.91 | 1.41 | (0.80–1.74) | 0.25 | Age (years) | 0.90 | (0.72–1.26) | 0.79 | 0.85 | (0.65–1.31) | 0.61 | KPS score, (%) | | | | | | | <70 | 1 | | | 1 | | | ≥70 | 0.63 | (0.45–0.89) | 0.01 | 0.58 | (0.39–0.76) | 0.01 | Steroid use | | | | | | | No | 1 | | | | | | Yes | 0.90 | (0.71–1.27) | 0.85 | 0.81 | (0.62–1.27) | 0.63 | Type of first surgery, (%) | | | | | | | Biopsy/partial resection | 1 | | | 1 | | | Subtotal/total resection | 0.76 | (0.38–1.23) | 0.51 | 0.82 | (0.49–1.38) | 0.74 | MGMT status | | | | | | | Unmethylated | 1 | | | 1 | | | Methylated | 0.95 | (0.67–1.35) | 0.82 | 0.88 | (0.58–1.26) | 0.71 | Time from original diagnosis (months) | | | | | | | <12 | 1 | | | 1 | | | ≥12 | 1.54 | (0.64–2.09) | 0.46 | 1.41 | (0.69–1.99) | 0.53 | Second surgery before treatment | | | | | | | No | 1 | | | | | | Yes | 0.87 | (0.57–1.31) | 0.90 | | | | Maximum tumor diameter (mm) | 0.73 | (0.45–1.39) | 0.47 | | | |
|
|