Research Article
Retrospective Analysis of Bevacizumab in Combination with Fotemustine in Chinese Patients with Recurrent Glioblastoma Multiforme
Table 4
Summary of adverse events.
| | Adverse event | Grade: number of patients | | 1 | 2 | 3 | 4 |
| | Nonhematologic toxicity | | | | | | Fatigue | 55 | 16 | 5 | — | | Proteinuria | 23 | 28 | — | — | | Hypertension | 8 | 13 | 4 | 3 | | Hypophonia | 12 | — | — | — | | Hyperpigmentation | 5 | — | — | — | | Hemorrhage, CNS | 5 | 2 | — | — | | Hemorrhage, GI | — | 2 | — | — | | Epistaxis | 4 | — | — | — | | Stroke | 1 | 1 | 1 | — | | DVT | — | 2 | 3 | — | | PE | 3 | 1 | 1 | — | | Wound dehiscence | 4 | 1 | 1 | — | | Infection | 2 | — | — | — | | Rash | — | — | — | — | | GI perforation/fistula | — | — | — | — | | Transaminase elevation | — | — | — | — | | Hematologic toxicity | — | — | — | — | | Anemia | 4 | 2 | 2 | — | | Neutropenia | 5 | 6 | 18 | 3 | | Thrombocytopenia | 9 | 17 | 14 | 2 |
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