Research Article

Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

Figure 2

TM-1 administered 3 or 4 h after injury reduced the TBI-induced AQP1 mRNA expression measured 8 and 24 h after TBI. Relative AQP1 mRNA expression was measured by reverse transcription Q-PCR using β-actin (a) and Gapdh (b) as reference genes. AQP1 mRNA expression significantly decreased following TM-1 administration (10 mg/kg) at 3 and 4 h after injury in the rats sacrificed 8 or 24 h after injury, respectively. Compared with the TBI + veh groups, the TM-1 treated groups exhibited significantly decreased mRNA expression. Data are expressed as mean ± SD (/group). TBI + veh group compared with the sham-operated group; and TM-1 treated group compared with the TBI + veh groups; , comparison between mRNA expression following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 or 24 h after TBI.
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