Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

Figure 4

TM-1 administered 3 or 4 h after injury reduced the TBI-induced AQP4 mRNA expression measured 8 and 24 h after TBI. (a) β-actin and (b) Gapdh as reference genes. AQP4 mRNA expression significantly decreased following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 or 24 h after injury, respectively. Compared with the TBI + veh groups, the TM-1 treated groups exhibited significantly decreased mRNA expression. Data are expressed as mean ± SD (/group). TBI + veh group compared with the sham-operated group; and compared with the TBI + veh groups; , comparison between mRNA expression following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 or 24 h after TBI.

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(b)