BioMed Research International / 2015 / Article / Tab 3

Research Article

The TF-miRNA Coregulation Network in Oral Lichen Planus

Table 3

Functional enrichment analysis of genes in network modules.

Network moduleEnriched functions related to OLP value (<0.05)

Module 1GO:0030901~midbrain development0.00337086
GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen0.00560592
GO:0008285~negative regulation of cell proliferation0.01400315
GO:0007600~sensory perception0.032006
GO:0007435~salivary gland morphogenesis0.0376765
GO:0002052~positive regulation of neuroblast proliferation0.04294326

Module 2GO:0004623~phospholipase A2 activity0.00233
GO:0050877~neurological system process0.00764739
GO:0051606~detection of stimulus0.04745557

Module 3GO:0001525~angiogenesis0.00589117
GO:0005829~cytosol0.00679876
GO:0042060~wound healing0.01651834
GO:0045740~positive regulation of DNA replication0.01978034
GO:0007173~epidermal growth factor receptor signaling pathway0.01978034
GO:0015629~actin cytoskeleton0.04636455

Module 4GO:0006879~cellular iron ion homeostasis0.00604241
GO:0000041~transition metal ion transport0.029349054
GO:0055114~oxidation reduction0.03217
hsa00980:Metabolism of xenobiotics by cytochrome P4500.03978611

Module 5GO:0003707~steroid hormone receptor activity0.00495459
GO:0006766~vitamin metabolic process0.01044366
GO:0001523~retinoid metabolic process0.04657368
GO:0006776~vitamin A metabolic process0.04657368

Module 6GO:0008395~steroid hydroxylase activity0.02851299
GO:0005887~integral to plasma membrane0.02900047
GO:0008202~steroid metabolic process0.04570667