The TF-miRNA Coregulation Network in Oral Lichen Planus

Table 3

Functional enrichment analysis of genes in network modules.


Network module	Enriched functions related to OLP	value (<0.05)

Module 1	GO:0030901~midbrain development	0.00337086
	GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.00560592
	GO:0008285~negative regulation of cell proliferation	0.01400315
	GO:0007600~sensory perception	0.032006
	GO:0007435~salivary gland morphogenesis	0.0376765
	GO:0002052~positive regulation of neuroblast proliferation	0.04294326

Module 2	GO:0004623~phospholipase A2 activity	0.00233
	GO:0050877~neurological system process	0.00764739
	GO:0051606~detection of stimulus	0.04745557

Module 3	GO:0001525~angiogenesis	0.00589117
	GO:0005829~cytosol	0.00679876
	GO:0042060~wound healing	0.01651834
	GO:0045740~positive regulation of DNA replication	0.01978034
	GO:0007173~epidermal growth factor receptor signaling pathway	0.01978034
	GO:0015629~actin cytoskeleton	0.04636455

Module 4	GO:0006879~cellular iron ion homeostasis	0.00604241
	GO:0000041~transition metal ion transport	0.029349054
	GO:0055114~oxidation reduction	0.03217
	hsa00980:Metabolism of xenobiotics by cytochrome P450	0.03978611

Module 5	GO:0003707~steroid hormone receptor activity	0.00495459
	GO:0006766~vitamin metabolic process	0.01044366
	GO:0001523~retinoid metabolic process	0.04657368
	GO:0006776~vitamin A metabolic process	0.04657368

Module 6	GO:0008395~steroid hydroxylase activity	0.02851299
	GO:0005887~integral to plasma membrane	0.02900047
	GO:0008202~steroid metabolic process	0.04570667