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BioMed Research International
Volume 2015, Article ID 731292, 10 pages
http://dx.doi.org/10.1155/2015/731292
Review Article

Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery

Pharmacogenomics Lab, Department of Pharmacology, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 19 August 2015; Revised 4 October 2015; Accepted 4 October 2015

Academic Editor: Luca Cucullo

Copyright © 2015 Md. Mirazul Islam and Zahurin Mohamed. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The blood-brain barrier (BBB) is a dynamic and highly selective permeable interface between central nervous system (CNS) and periphery that regulates the brain homeostasis. Increasing evidences of neurological disorders and restricted drug delivery process in brain make BBB as special target for further study. At present, neurovascular unit (NVU) is a great interest and highlighted topic of pharmaceutical companies for CNS drug design and delivery approaches. Some recent advancement of pharmacology and computational biology makes it convenient to develop drugs within limited time and affordable cost. In this review, we briefly introduce current understanding of the NVU, including molecular and cellular composition, physiology, and regulatory function. We also discuss the recent technology and interaction of pharmacogenomics and bioinformatics for drug design and step towards personalized medicine. Additionally, we develop gene network due to understand NVU associated transporter proteins interactions that might be effective for understanding aetiology of neurological disorders and new target base protective therapies development and delivery.