BioMed Research International / 2015 / Article / Fig 1

Review Article

The Immune System in Hepatocellular Carcinoma and Potential New Immunotherapeutic Strategies

Figure 1

Mechanisms responsible for inefficient T-cell responses in HCC. Failure of TAA processing and presentation; suppression of CD4+ and CD8+ cells by Treg; insufficient levels of CD4 help; negative regulation by PD-1/PDL1 pathway.

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