Plant Antimicrobial Peptides as Potential Anticancer Agents

Figure 1

Alignment of amino acid sequences from thionins. The asterisk indicates amino acids conserved in all family members. The cysteine residues present in all sequences and relevant to the classification are indicated in red letters. The red arrows indicate the three residues that are essential for binding to the head regions of the membrane lipids. The hydrophobic residues are shaded in yellow. The thionin sequences included in the alignment were pyrularia (GenBank accession P07504) from Pyrularia pubera, viscotoxins 1-PS (GenBank accession P01537), A1 (GenBank accession 3C8P_A), A2 (GenBank accession P32880), A3 (GenBank accession VTVAA3), B (GenBank accession 1JMP_A), B2 (GenBank accession 2V9B_B), and C1 (GenBank accession P83554) from Viscum album, phoratoxins A (GenBank accession P01539), B, C, D, E, and F [24] from Phoradendron tomentosum, and crambin (GenBank accession P01542) from Crambe hispanica.