Clinical Study
New Onset Diplopia in Patients with Nasopharyngeal Carcinoma following Concurrent Chemoradiotherapy: Clinical Features and Etiology
Table 2
Clinical manifestations of NPC patients with new onset diplopia in relation to different etiologies.
| | | Tumor recurrence
= 12 (52%) | Skull base ORN
= 3 (13%) | Radiation neuropathy
= 8 (35%) |
| | Latency between CCRT completion and diplopic onset (range, months) | 44 (16–60) | 48 (7–96) | 70 (40–144) |
| | Involvement of cranial nerve | | | | | Unilateral nerve III | 0 | 1 | 0 | | Unilateral nerve VI | 11 | 2 | 8 | | Bilateral nerve VI | 1 | 0 | 0 |
| | Severity of ocular duction deficit at diagnosis | Complete palsy: 4
Incomplete palsy: 8 | Complete palsy: 3
Incomplete palsy: 0 | Complete palsy: 0
Incomplete palsy: 8 |
| | Progression of ocular duction deficit | Persisted complete palsy: 4
Rapid progression: 8
Slow progression: 0
Stable condition: 0
Recovery: 0 | Persisted complete palsy: 2
Rapid progression: 0
Slow progression: 0
Stable condition: 0
Recovery: 1 | Persisted complete palsy: 0
Rapid progression: 0
Slow progression: 3
Stable condition: 5
Recovery: 0 |
|
|
= number of patients; ORN = osteoradionecrosis.
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