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BioMed Research International
Volume 2015, Article ID 738528, 6 pages
http://dx.doi.org/10.1155/2015/738528
Research Article

The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil

1Medical Sciences Post-Graduate Program, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
2Departamento de Genética, Universidade Federal do Rio de Janeiro, 21941-901 Rio de Janeiro, RJ, Brazil
3Programa de Genética, Instituto Nacional de Câncer, 21941-901 Rio de Janeiro, RJ, Brazil
4Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil

Received 2 June 2015; Revised 5 September 2015; Accepted 20 September 2015

Academic Editor: Pere Domingo

Copyright © 2015 Carmen Andréa F. Lopes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. UNAIDS, “GLOBAL REPORT: UNAIDS report on the global AIDS epidemia 2013,” http://www.unaids.org/.
  2. D. Costagliola, B. Ledergerber, C. Torti, and et al, “Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study,” The Lancet Infectious Diseases, vol. 12, no. 2, pp. 119–127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Doherty, N. Ford, M. Vitoria, G. Weiler, and G. Hirnschall, “The 2013 WHO guidelines for antiretroviral therapy: evidence-based recommendations to face new epidemic realities,” Current Opinion in HIV and AIDS, vol. 8, no. 6, pp. 528–534, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. European AIDS Clinical Society (EACS), 2013, http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:October+2013#1.
  5. Panel on Antiretroviral Guidelines for Adults and Adolescents, Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, Department of Health and Human Services (DHHS), Bethesda, Md, USA, 2014, http://www.guideline.gov/content.aspx?id=48047.
  6. M. A. Thompson, J. A. Aberg, J. F. Hoy et al., “Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel,” The Journal of the American Medical Association, vol. 308, no. 4, pp. 387–402, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. R. E. Barth, M. F. S. van der Loeff, R. Schuurman, A. I. Hoepelman, and A. M. Wensing, “Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review,” The Lancet Infectious Diseases, vol. 10, no. 3, pp. 155–166, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. C. Hosseinipour, R. K. Gupta, G. Van Zyl, J. J. Eron, and J. B. Nachega, “Emergence of HIV drug resistance during first- and second-line antiretroviral therapy in resource-limited settings,” Journal of Infectious Diseases, vol. 207, supplement 2, pp. S49–S56, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. J. D. Siliciano and R. F. Siliciano, “Recent trends in HIV-1 drug resistance,” Current Opinion in Virology, vol. 3, no. 5, pp. 487–494, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Al-Dakkak, S. Patel, E. McCann, A. Gadkari, G. Prajapati, and E. M. Maiese, “The impact of specific HIV treatment-related adverse events on adherence to antiretroviral therapy: a systematic review and meta-analysis,” AIDS Care, vol. 25, no. 4, pp. 400–414, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. WHO, “HIV drug resistance report 2012,” 2012, http://www.who.int/hiv/pub/drugresistance/report2012/en/.
  12. E. J. Arts and D. J. Hazuda, “HIV-1 antiretroviral drug therapy,” Cold Spring Harbor Perspectives in Medicine, vol. 2, no. 4, Article ID a007161, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. M. S. Medeiros, E. A. G. Arruda, R. L. Guerrant, C. C. Brown, and A. A. M. Lima, “Impact of the number of failed therapeutic regimes on the development of resistance mutations to HIV-1 in northeast Brazil,” Brazilian Journal of Infectious Diseases, vol. 11, no. 5, pp. 451–455, 2007. View at Google Scholar · View at Scopus
  14. M. W. Tang and R. W. Shafer, “HIV-1 antiretroviral resistance: scientific principles and clinical applications,” Drugs, vol. 72, no. 9, pp. e1–e25, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Bonner, A. Mezochow, T. Roberts, N. Ford, and J. Cohn, “Viral load monitoring as a tool to reinforce adherence: a systematic review,” Journal of Acquired Immune Deficiency Syndromes, vol. 64, no. 1, pp. 74–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. R. K. Gupta, A. Hill, A. W. Sawyer et al., “Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis,” The Lancet Infectious Diseases, vol. 9, no. 7, pp. 409–417, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. L. Martínez-Cajas, N. Pant-Pai, M. B. Klein, and M. A. Wainberg, “Role of genetic diversity amongst HIV-1 non-B subtypes in drug resistance: a systematic review of virologic and biochemical evidence,” AIDS Reviews, vol. 10, no. 4, pp. 212–223, 2008. View at Google Scholar · View at Scopus
  18. M. A. Wainberg and B. G. Brenner, “The impact of HIV genetic polymorphisms and subtype differences on the occurrence of resistance to antiretroviral drugs,” Molecular Biology International, vol. 2012, Article ID 256982, 10 pages, 2012. View at Publisher · View at Google Scholar
  19. J. C. Couto-Fernandez, C. Silva-De-Jesus, V. G. Veloso et al., “Human immunodeficiency virus type 1 (HIV-1) genotyping in Rio de Janeiro, Brazil: assessing subtype and drug-resistance associated mutations in HIV-1 infected individuals failing highly active antiretroviral therapy,” Memorias do Instituto Oswaldo Cruz, vol. 100, no. 1, pp. 73–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. M. S. Cavalcanti, H. R. Lacerda, A. M. De Brito, S. Pereira, D. Medeiros, and S. Oliveira, “Antiretroviral resistance in individuals presenting therapeutic failure and subtypes of the human immunodeficiency virus type 1 in the Northeast Region of Brazil,” Memorias do Instituto Oswaldo Cruz, vol. 102, no. 7, pp. 785–792, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. V. M. Toledo, D. S. de Carvalho, L. Romagnoli et al., “HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil,” Brazilian Journal of Infectious Diseases, vol. 14, no. 4, pp. 360–371, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. R. Westin, F. M. Biscione, M. Fonseca et al., “Resistance-associated mutation prevalence according to subtypes B and non-B of HIV type 1 in antiretroviral-experienced patients in Minas Gerais, Brazil,” AIDS Research and Human Retroviruses, vol. 27, no. 9, pp. 981–987, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. L. A. Inocencio, A. A. Pereira, M. C. A. Sucupira et al., “Brazilian network for HIV drug resistance surveillance: a survey of individuals recently diagnosed with HIV,” Journal of the International AIDS Society, vol. 12, article 20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Sprinz, E. M. Netto, M. Patelli et al., “Primary antiretroviral drug resistance among HIV type 1-infected individuals in Brazil,” AIDS Research and Human Retroviruses, vol. 25, no. 9, pp. 861–867, 2009. View at Publisher · View at Google Scholar
  25. B. C. Carvalho, L. P. V. Cardoso, S. Damasceno, and M. M. D. A. Stefani, “Moderate prevalence of transmitted drug resistance and interiorization of HIV type 1 subtype C in the inland north state of Tocantins, Brazil,” AIDS Research and Human Retroviruses, vol. 27, no. 10, pp. 1081–1087, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. É. Arruda, L. Simões, C. Sucupira et al., “Short communication: intermediate prevalence of HIV type 1 primary antiretroviral resistance in Ceará State, Northeast Brazil,” AIDS Research and Human Retroviruses, vol. 27, no. 2, pp. 153–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. K. V. Gaspareto, F. M. M. D. A. Mello, J. R. C. Dias et al., “Genetic diversity and primary resistance among HIV-1-positive patients from Maringá, Paraná, Brazil,” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 54, no. 4, pp. 207–213, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. E. A. J. M. Soares, A. M. B. Martínez, T. M. Souza et al., “HIV-1 subtype C dissemination in southern Brazil,” AIDS, vol. 19, supplement 4, pp. S81–S86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Munerato, M. C. Sucupira, M. P. R. Oliveros et al., “HIV type 1 antiretroviral resistance mutations in subtypes B, C, and F in the city of São Paulo, Brazil,” AIDS Research and Human Retroviruses, vol. 26, no. 3, pp. 265–273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. S. E. M. Almeida, R. M. De Medeiros, D. M. Junqueira et al., “Temporal dynamics of HIV-1 circulating subtypes in distinct exposure categories in southern Brazil,” Virology Journal, vol. 9, article 306, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Alcalde, M. L. Guimarães, A. J. S. Duarte, and J. Casseb, “Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil,” Virology Journal, vol. 9, article 156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Gräf and A. R. Pinto, “The increasing prevalence of HIV-1 subtype C in Southern Brazil and its dispersion through the continent,” Virology, vol. 435, no. 1, pp. 170–178, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. L. F. A. Machado, M. O. G. Ishak, A. C. R. Vallinoto et al., “Molecular epidemiology of HIV type 1 in northern Brazil: identification of subtypes C and D and the introduction of CRF02_AG in the Amazon region of Brazil,” AIDS Research and Human Retroviruses, vol. 25, no. 10, pp. 961–966, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. O. Macêdo, L. M. Ferreira, C. A. F. Lopes, R. C. M. Sousa, J. R. M. Araújo, and P. F. D. C. Vasconcelos, “Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006,” Revista Pan-Amazônica de Saúde, vol. 3, no. 2, pp. 11–16, 2012. View at Publisher · View at Google Scholar
  35. Ministério da Saúde, Boletim Epidemiológico HIV/AIDS, vol. 64, Ministério da Saúde, Brasília, Brazil, 2013.
  36. R. L. Hamers, K. C. E. Sigaloff, A. M. Wensing et al., “Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-saharan african countries: implications for second-line ART strategies,” Clinical Infectious Diseases, vol. 54, no. 11, pp. 1660–1669, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Hill, A. McBride, A. W. Sawyer, N. Clumeck, and R. K. Gupta, “Resistance at virological failure using boosted protease inhibitors versus nonnucleoside reverse transcriptase inhibitors as first-line antiretroviral therapy—implications for sustained efficacy of ART in resource-limited settings,” The Journal of Infectious Diseases, vol. 207, supplement 2, pp. S78–S84, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. V. A. Johnson, V. Calvez, H. F. Günthard et al., “Update of the drug resistance mutations in HIV-1: March 2013,” Topics in Antiviral Medicine, vol. 21, no. 1, pp. 6–14, 2013. View at Google Scholar · View at Scopus
  39. R. W. Shafer and J. M. Schapiro, “HIV-1 drug resistance mutations: an updated framework for the second decade of HAART,” AIDS Reviews, vol. 10, no. 2, pp. 67–84, 2008. View at Google Scholar · View at Scopus
  40. J. Vingerhoets, L. Tambuyzer, H. Azijn et al., “Resistance profile of etravirine: combined analysis of baseline genotypic and phenotypic data from the randomized, controlled Phase III clinical studies,” AIDS, vol. 24, no. 4, pp. 503–514, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. J. M. Llibre, J. R. Santos, T. Puig et al., “Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz,” Journal of Antimicrobial Chemotherapy, vol. 62, no. 5, pp. 909–913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. A. N. Martins, M. B. Arruda, A. W. Aleixo et al., “Prevalence of etravirine-associated mutations in clinical samples with genotypic resistance to nevirapine and efavirenz in Brazilian Clinics,” Journal of Acquired Immune Deficiency Syndromes, vol. 57, supplement 3, pp. S193–S196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. J. E. Vidal, A. T. W. Song, M. L. Matos et al., “High rate of virologic suppression with darunavir/ritonavir plus optimized background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil,” Brazilian Journal of Infectious Diseases, vol. 17, no. 1, pp. 41–47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. R. W. Lihana, D. Ssemwanga, A. Abimiku, and N. Ndembi, “Update on HIV-1 diversity in Africa: a decade in review,” AIDS Reviews, vol. 14, pp. 83–100, 2012. View at Google Scholar · View at Scopus
  45. C. Alteri, A. Artese, G. Beheydt et al., “Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen,” The Journal of Antimicrobial Chemotherapy, vol. 68, no. 10, pp. 2205–2209, 2013. View at Google Scholar · View at Scopus
  46. M. Azam, A. Malik, M. Rizvi, S. Singh, P. Gupta, and A. Rai, “Emergence of drug resistance-associated mutations in HIV-1 subtype C protease gene in north India,” Virus Genes, vol. 47, no. 3, pp. 422–428, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. K. A. Sutherland, J. Ghosn, J. Gregson et al., “HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir,” Journal of Antimicrobial Chemotherapy, vol. 70, no. 1, pp. 243–248, 2015. View at Publisher · View at Google Scholar