Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts
Table 2
Effect of OS extracts on hematological parameters in rats during 14-day oral acute toxicity study.
Parameter
Unit
CON
OSA
OSF
OSE
Male
WBC
109/L
5.45 ± 0.54
6.12 ± 1.24
5.6 ± 0.52
6.28 ± 0.87
RBC
1012/L
5.81 ± 0.20
5.7 ± 0.16
6.03 ± 0.21
5.62 ± 0.29
PLT
109/L
942.2 ± 83.22
865.5 ± 158.5
779.8 ± 215.8
866 ± 144.2
LYM
109/L
4.05 ± 0.41
6.65 ± 1.09
4.25 ± 0.36
5.07 ± 0.69
Hb
g/dL
12.25 ± 0.37
12.15 ± 0.35
12.37 ± 0.27
12.65 ± 0.38
HCT
%
38.32 ± 1.18
37.6 ± 1.14
38.9 ± 0.84
37.38 ± 1.85
MCV
fL
66.03 ± 0.57
65.93 ± 0.44
64.68 ± 1.06
66.62 ± 0.88
MCH
pg
21.12 ± 0.11
21.3 ± 0.08
20.53 ± 0.20
22.28 ± 1.16
MCHC
g/dL
31.98 ± 0.20
32.3 ± 0.15
31.78 ± 0.38
33.5 ± 1.56
RDW
%
13.97 ± 0.49
13.45 ± 0.31
14.18 ± 0.66
14.1 ± 0.28
PDW
fL
8.14 ± 0.09
8.57 ± 0.25
9.22 ± 0.71
9.17 ± 0.42
MPV
fL
6.88 ± 0.10
7.08 ± 0.11
7.2 ± 0.28
7.48 ± 0.18
P-LCR
%
5.8 ± 0.50
6.95 ± 0.81
8.75 ± 2.32
9.82 ± 2.02
Female
WBC
109/L
5.13 ± 0.42
4.02 ± 0.19
6.25 ± 0.65
5.95 ± 1.0
RBC
1012/L
6.62 ± 0.13
6.51 ± 0.26
6.31 ± 0.12
6.44 ± 0.16
PLT
109/L
843.7 ± 98.89
1018 ± 151.5
991 ± 181.4
942.2 ± 109.6
LYM
109/L
4.12 ± 0.43
2.58 ± 0.37
4.97 ± 0.51
4.92 ± 0.85
Hb
g/dL
13.45 ± 0.18
13.55 ± 0.51
13.7 ± 0.2
13.35 ± 0.23
HCT
%
40.1 ± 0.65
40.57 ± 1.82
38.8 ± 0.77
39.88 ± 0.81
MCV
fL
60.58 ± 0.74
62.27 ± 0.81
61.55 ± 0.66
62.02 ± 0.66
MCH
pg
20.82 ± 0.30
20.82 ± 0.25
21.18 ± 0.12
21.32 ± 0.24
MCHC
g/dL
33.55 ± 0.13
33.47 ± 0.29
34.42 ± 0.42
34.38 ± 0.37
RDW
%
12.2 ± 0.31
12.2 ± 0.20
11.65 ± 0.41
11.4 ± 0.17
PDW
fL
8.43 ± 0.23
8.1 ± 0.14
8.37 ± 0.22
8.33 ± 0.17
MPV
fL
7.08 ± 0.12
6.79 ± 0.10
6.87 ± 0.13
6.95 ± 0.13
P-LCR
%
6.45 ± 0.49
5.42 ± 0.47
5.62 ± 0.54
5.87 ± 0.54
Data are expressed as mean ± standard error of the mean (SEM) and analyzed by one-way ANOVA, followed by Dunnett’s test () as compared to the respective parameter value of control groups (CON) (6 males and 6 females).
