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BioMed Research International
Volume 2015, Article ID 743051, 11 pages
Research Article

Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model

1Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah 51412, Saudi Arabia
2Department of Pharmacology & Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia
3Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia
4Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

Received 16 September 2014; Revised 6 November 2014; Accepted 13 November 2014

Academic Editor: Wan-Liang Lu

Copyright © 2015 Hamzah M. Maswadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarcoma in a murine model. Fibrosarcoma was induced in mice by injecting benzopyrene (BAP) and tumor-bearing mice were treated with various formulations of etoposide, including etoposide entrapped camel milk phospholipids liposomes (ETP-Cam-liposomes) and etoposide-loaded DPPC-liposomes (ETP-DPPC-liposomes). The tumor-bearing mice treated with ETP-Cam-liposomes showed slow progression of tumors and increased survival compared to free ETP or ETP-DPPC-liposomes. These results suggest that ETP-Cam-liposomes may prove to be a better drug delivery system for anticancer drugs.