Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

Table 1

Time dependent changes in the biomarkers of oxidative stress in rodent models of epilepsy and in human epileptic patients.

(a)

Rat kainate model	4 hr	8 hr	16 hr	24 hr	48 hr	3–7 d	3 week	Human patients
GSH/GSSG ratio								GSH/GSSG ratio
Lipid peroxidation (TBA assay)								Lipid peroxidation (TBA assay)
Protein oxidation								Protein oxidation
SOD								SOD
NADPH oxidase								catalase
catalase								aconitase
aconitase								DNA damage (OdG assay)
DNA damage (OHdG assay)

(b)

Rat kindling model	4 hr	8 hr	16 hr	24 hr	48 hr	3–7 d	3 week
GSH/GSSG ratio
Lipid peroxidation (TBA assay)
SOD
aconitase

(c)

Rat Pilocarpine model	4 hr	8 hr	16 hr	24 hr	48 hr	3–7 d	3 week
GSH/GSSG ratio
Lipid peroxidation (TBA assay)
SOD
catalase

(d)

Mice kainic acid model	4 hr	8 hr	16 hr	24 hr	48 hr	3–7 d	3 week
GSH/GSSG ratio
Lipid peroxidation (TBA assay)

Rat kainate model [48–52], Rat kindling model [53–57], Rat pilocarpine model [58–60], Mouse kainate model [61–64], Human patients [65–67].