Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites

<div>Number of poses in binding site for various ligands. (1) Beta-adrenergic receptor/carazolol (PDB ID: 2rhn_A), a typical tight-binding receptor/ligand complex; (2) AcrB/minocycline (28 heavy atoms); (3) AcrB/acridine orange (20 heavy atoms); and (4) AcrB/toluene (7 heavy atoms).</div>

BioMed Research International

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Figure 1

Figure 1: Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites 