Evaluation of the Efficacy of a Bacteriophage in the Treatment of Pneumonia Induced by Multidrug Resistance Klebsiella pneumoniae in Mice

Figure 6

Body weight loss, bacterial burden, and the phage number present in the lung after phage treatment of K. pneumoniae infection. Groups of 6 mice were inoculated via the intranasal route with 6 × 10⁷ CFU/mouse K. pneumoniae. PBS or phage 1513 (6 × 10⁷ PFU/mouse) was administered intranasally 2 h after infection. The numbers of bacteriophage (a) or bacteria (b) in the lung homogenates were determined. Mice were weighed (c). Bacteria counts and weight loss rate were significantly lower in the lung homogenate from the mice in the phage-treated group than in the control group ( and ). Bacteriophage counts were significantly higher in the infected group than in the noninfected animals ().

(a)

(b)

(c)