Extracellular Calcium-Dependent Modulation of Endothelium Relaxation in Rat Mesenteric Small Artery: The Role of Potassium Signaling

Figure 2

The concentration-dependent relaxation to ACh in the bath solutions containing either 4.2 mM ((a) ) or 5.9 mM ((b) ) . In the time-control experiments only the vehicle was supplied (). Responses were compared under control conditions and after preincubation with 100 μM L-NAME and 3 μM indomethacin. (c) and (d) show the areas under curve (AUC) for the concentration-responses shown in (a) and (b). ++ and +++ indicate and 0.001 for responses in the presence of 1 mM versus 2.5 mM . and indicate and 0.001 for responses before and after application of L-NAME and indomethacin.

(a)

(b)

(c)

(d)