Extracellular Calcium-Dependent Modulation of Endothelium Relaxation in Rat Mesenteric Small Artery: The Role of Potassium Signaling

Figure 6

Addition of 30 μM BaCl₂ to the solution containing 100 μM L-NAME and 3 μM indomethacin suppressed ACh-dependent relaxations. The concentration-response curves were constructed in the bath solutions with 4.2 mM ((a) ) and with 5.9 mM ((b) ) . (c) shows the areas under curves (AUC) as in (a) and (b). Changes in the sensitivities to ACh (pD₂) after addition of BaCl₂ are shown in (d). The effects of BaCl₂ on the maximal relaxations are shown in (e). indicates versus 1 mM .

(a)

(b)

(c)

(d)

(e)