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BioMed Research International
Volume 2015 (2015), Article ID 758346, 11 pages
http://dx.doi.org/10.1155/2015/758346
Research Article

Extracellular Calcium-Dependent Modulation of Endothelium Relaxation in Rat Mesenteric Small Artery: The Role of Potassium Signaling

1MEMBRANES, Department of Biomedicine, Health, Aarhus University, 8000 Aarhus, Denmark
2Department of Biomedicine, University of Copenhagen, Copenhagen, Denmark

Received 5 June 2015; Revised 11 August 2015; Accepted 16 August 2015

Academic Editor: Richardt G. Landgraf

Copyright © 2015 Lise Hangaard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. de Wit and S. E. Wölfle, “EDHF and gap junctions: important regulators of vascular tone within the microcirculation,” Current Pharmaceutical Biotechnology, vol. 8, no. 1, pp. 11–25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Shimokawa, H. Yasutake, K. Fujii et al., “The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation,” Journal of Cardiovascular Pharmacology, vol. 28, no. 5, pp. 703–711, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. S. L. Sandow, “Factors, fiction and endothelium-derived hyperpolarizing factor,” Clinical and Experimental Pharmacology and Physiology, vol. 31, no. 9, pp. 563–570, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. Garland, C. R. Hiley, and K. A. Dora, “EDHF: spreading the influence of the endothelium,” British Journal of Pharmacology, vol. 164, no. 3, pp. 839–852, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Edwards, M. Félétou, and A. H. Weston, “Endothelium-derived hyperpolarising factors and associated pathways: a synopsis,” Pflügers Archiv—European Journal of Physiology, vol. 459, no. 6, pp. 863–879, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Grgic, B. P. Kaistha, J. Hoyer, and R. Köhler, “Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses—relevance to cardiovascular pathologies and drug discovery,” British Journal of Pharmacology, vol. 157, no. 4, pp. 509–526, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. Sandow, C. B. Neylon, M. X. Chen, and C. J. Garland, “Spatial separation of endothelial small- and intermediate-conductance calcium-activated potassium channels (KCa) and connexins: possible relationship to vasodilator function?” Journal of Anatomy, vol. 209, no. 5, pp. 689–698, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. G. J. Crane, N. Gallagher, K. A. Dora, and C. J. Garland, “Small- and intermediate-conductance calcium-activated K+ channels provide different facets of endothelium-dependent hyperpolarization in rat mesenteric artery,” The Journal of Physiology, vol. 553, no. 1, pp. 183–189, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Busse, G. Edwards, M. Félétou, I. Fleming, P. M. Vanhoutte, and A. H. Weston, “EDHF: bringing the concepts together,” Trends in Pharmacological Sciences, vol. 23, no. 8, pp. 374–380, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A. H. Weston, E. L. Porter, E. Harno, and G. Edwards, “Impairment of endothelial SK Ca channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats,” British Journal of Pharmacology, vol. 160, no. 4, pp. 836–843, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. K. A. Dora, N. T. Gallagher, A. McNeish, and C. J. Garland, “Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries,” Circulation Research, vol. 102, no. 10, pp. 1247–1255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Edwards, K. A. Dora, M. J. Gardener, C. J. Garland, and A. H. Weston, “K+ is an endothelium-derived hyperpolarizing factor in rat arteries,” Nature, vol. 396, no. 6708, pp. 269–272, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Edwards and A. H. Weston, “Potassium and potassium clouds in endothelium-dependent hyperpolarizations,” Pharmacological Research, vol. 49, no. 6, pp. 535–541, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. K. A. Dora and C. J. Garland, “Properties of smooth muscle hyperpolarization and relaxation to K+ in the rat isolated mesenteric artery,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 280, no. 6, pp. H2424–H2429, 2001. View at Google Scholar · View at Scopus
  15. K. K. Bradley, J. H. Jaggar, A. D. Bonev et al., “Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells,” The Journal of Physiology, vol. 515, no. 3, pp. 639–651, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. A. H. Weston, M. Absi, D. T. Ward et al., “Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231,” Circulation Research, vol. 97, no. 4, pp. 391–398, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. M. J. Mulvany and W. Halpern, “Mechanical properties of vascular smooth muscle cells in situ,” Nature, vol. 260, no. 5552, pp. 617–619, 1976. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Smajilovic and J. Tfelt-Hansen, “Calcium acts as a first messenger through the calcium-sensing receptor in the cardiovascular system,” Cardiovascular Research, vol. 75, no. 3, pp. 457–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. H. Weston, M. Absi, E. Harno et al., “The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes,” British Journal of Pharmacology, vol. 154, no. 3, pp. 652–662, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hayashi, C. Kunii, T. Takahata, and T. Ishikawa, “ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase,” The American Journal of Physiology—Cell Physiology, vol. 286, no. 3, pp. C635–C646, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. T. von Hahn, I. Thiele, L. Zingaro et al., “Characterisation of the rat SK4/IK1 K+ channel,” Cellular Physiology and Biochemistry, vol. 11, no. 4, pp. 219–230, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. V. V. Matchkov, N. Moeller-Nielsen, V. S. Dam, Z. Nourian, D. M. B. Boedtkjer, and C. Aalkjaer, “The α2 isoform of the Na,K-pump is important for intercellular communication, agonist-induced contraction, and EDHF-like response in rat mesenteric arteries,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 303, no. 1, pp. H36–H46, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. T. Nelson and J. M. Quayle, “Physiological roles and properties of potassium channels in arterial smooth muscle,” The American Journal of Physiology—Cell Physiology, vol. 268, no. 4, pp. C799–C822, 1995. View at Google Scholar · View at Scopus
  24. T. A. Longden and M. T. Nelson, “Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow,” Microcirculation, vol. 22, no. 3, pp. 183–196, 2015. View at Publisher · View at Google Scholar
  25. M. Glavind-Kristensen, V. Matchkov, V. B. Hansen, A. Forman, H. Nilsson, and C. Aalkjær, “KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries,” British Journal of Pharmacology, vol. 143, no. 7, pp. 872–880, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. V. V. Matchkov, H. Gustafsson, A. Rahman et al., “Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication,” Circulation Research, vol. 100, no. 7, pp. 1026–1035, 2007. View at Publisher · View at Google Scholar
  27. T. Haruna, M. Horie, I. Kouchi et al., “Coordinate interaction between ATP-sensitive K+ channel and Na+,K+-ATPase modulates ischemic preconditioning,” Circulation, vol. 98, no. 25, pp. 2905–2910, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. W.-G. Ding, L.-P. He, M. Omatsu-Kanbe, and H. Kitasato, “A possible role of the ATP-sensitive potassium ion channel in determining the duration of spike-bursts in mouse pancreatic beta-cells,” Biochimica et Biophysica Acta—Biomembranes, vol. 1279, no. 2, pp. 219–226, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Köhler and P. Ruth, “Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice,” Pflügers Archiv—European Journal of Physiology, vol. 459, no. 6, pp. 969–976, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. J. M. Doughty, J. P. Boyle, and P. D. Langton, “Potassium does not mimic EDHF in rat mesenteric arteries,” British Journal of Pharmacology, vol. 130, no. 5, pp. 1174–1182, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. J. M. Doughty, J. P. Boyle, and P. D. Langton, “Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium,” British Journal of Pharmacology, vol. 132, no. 1, pp. 293–301, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Harris, P. E. M. Martin, W. H. Evans, D. A. Kendall, T. M. Griffith, and M. D. Randall, “Role of gap junctions in endothelium-derived hyperpolarizing factor responses and mechanisms of K+-relaxation,” European Journal of Pharmacology, vol. 402, no. 1-2, pp. 119–128, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. P. S. Lacy, G. Pilkington, R. Hanvesakul, H. J. Fish, J. P. Boyle, and H. Thurston, “Evidence against potassium as an endothelium-derived hyperpolarizing factor in rat mesenteric small arteries,” British Journal of Pharmacology, vol. 129, no. 3, pp. 605–611, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. G. R. Richards, A. H. Weston, M. P. Burnham, M. Félétou, P. M. Vanhoutte, and G. Edwards, “Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor,” British Journal of Pharmacology, vol. 134, no. 1, pp. 1–5, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. D. X. P. Brochet and P. D. Langton, “Dual effect of initial [K] on vascular tone in rat mesenteric arteries,” Pflügers Archiv, vol. 453, no. 1, pp. 33–41, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. P. E. M. Martin, N. S. Hill, B. Kristensen, R. J. Errington, and T. M. Griffith, “Ouabain exerts biphasic effects on connexin functionality and expression in vascular smooth muscle cells,” British Journal of Pharmacology, vol. 140, no. 7, pp. 1261–1271, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. V. V. Matchkov, “Mechanisms of cellular synchronization in the vascular wall. Mechanisms of vasomotion,” Danish Medical Bulletin, vol. 57, no. 10, Article ID B4191, 2010. View at Google Scholar · View at Scopus