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BioMed Research International
Volume 2015, Article ID 758684, 11 pages
http://dx.doi.org/10.1155/2015/758684
Research Article

Levonorgestrel Inhibits Human Endometrial Cell Proliferation through the Upregulation of Gap Junctional Intercellular Communication via the Nuclear Translocation of Ser255 Phosphorylated Cx43

1Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China
2Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Care Centers, Southern Medical University, Shenzhen, Guangdong 518000, China
3Pathology Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China
4Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215325, China

Received 12 July 2014; Revised 27 September 2014; Accepted 28 September 2014

Academic Editor: Ignacio Zapardiel

Copyright © 2015 Xiaomiao Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The histology of the endometrium in a 30-year old woman with endometrial intraepithelial neoplasms (EIN) and eventually achieving a live birth showed the high-grade atypical endometrial hyperplasia (EH) of the glandular cells with relatively less stromal cells was observed, before the treatment of LNG-IUS (A); the high-grade atypical EH had inverted to the low to medium-grade atypical EH with partly stromal decidualization, after the treatment of LNG-IUS for 6 months; and was reverted to the normal endometrium with atrophy of endometrial glandular cells and obvious stromal decidualization, after the treatment of LNG-IUS for 12 months.

  1. Supplementary Material