**Data**: Initial tensor , rotation matrices, number of Monte Carlo trials , SNR = , GES and . |

**Result**: Response surface of |

**for** **to** **do** |

* *Obtain (a rotated version of ); |

* ***for** **to** **do** |

* * (i) Simulate the diffusion signal at the sampling points defined by the GES under evaluation using the |

* * * *Stejskal and Tanner [18] equation ; |

* * * *(ii) Add Rician distributed noise to the synthetic signal to obtain given SNR; |

* * * *(iii) Compute the diffusion tensor and the corresponding ; |

* *(iv) Record the mean signal deviation (); |