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BioMed Research International
Volume 2015 (2015), Article ID 760758, 6 pages
http://dx.doi.org/10.1155/2015/760758
Review Article

Molecular Targets in Alzheimer’s Disease: From Pathogenesis to Therapeutics

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Received 23 August 2015; Revised 2 November 2015; Accepted 3 November 2015

Academic Editor: Mikko Hiltunen

Copyright © 2015 Xuan Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer’s disease (AD) is characterized by progressive cognitive decline usually beginning with impairment in the ability to form recent memories. Nonavailability of definitive therapeutic strategy urges developing pharmacological targets based on cell signaling pathways. A great revival of interest in nutraceuticals and adjuvant therapy has been put forward. Tea polyphenols for their multiple health benefits have also attracted the attention of researchers. Tea catechins showed enough potentiality to be used in future as therapeutic targets to provide neuroprotection against AD. This review attempts to present a concise map of different receptor signaling pathways associated with AD with an insight into drug designing based on the proposed signaling pathways, molecular mechanistic details of AD pathogenesis, and a scientific rationale for using tea polyphenols as proposed therapeutic agents in AD.