Clinical Study
Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines
Figure 4
Effect of STA, ASA, and the combination of both treatments on prostate cancer cell lines invasion capacity. Values for PC3 cell line migration capacity (a) are presented as the difference between the wound-healing speed (μm2/h) before and after 48 h of treatment calculated using Image J software and values for LNCaP migration (b) are presented as crystal violet absorbance/well after 48 h of treatment. Both cell lines were treated with different conditions: nontreated cells, control (C) and control with DMSO (C(DMSO)), and cells treated with statin (STA), aspirin (ASA), and a combination of both statin and aspirin (STA + ASA) (for further details, see Section 2). The bars represent the mean ± SEM. Values that are significantly different by one-way analysis of variance (ANOVA) from the C(DMSO) group are indicated by . (c) Phase contrast 10x images from migration mode during wound-healing assay at 48 h after treatment for PC3 cell line.
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