Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension
Resveratrol regulates the expression of cell cycle regulatory molecules through SIRT1. (a) Resveratrol increased SIRT1 and p21 expression but decreased cyclin D1 and cyclin E expression in HPASMCs (). The densitometric quantification was normalized to GAPDH. Data are shown as means ± SEM for three independent experiments. , versus vehicle. (b) SIRT1 RNAi reversed the regulation of p21, cyclin D1, and cyclin E expression level by resveratrol . , versus vehicle pretreated Ad-U6 group; , versus resveratrol pretreated Ad-U6 group.
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