The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data

Table 1

Characteristics of the studies included in the meta-analysis.

Author	Year	Race	NP	Positive (number)	Positive (%)	Histology	Stage	Test method	HR estimate	Cutoff	Result
Seo et al. [29]	2014	Japan	369	33	8.9	NSCLC	I–III	FISH	HR + CI	≥6.2	NS
Cihoric et al. [26]	2014	Switzerland	329	41	12.5	NSCLC	I-II	FISH	HR + CI	≥2	Poor
Toschi et al. [30]	2014	America	445	74	16.6	NSCLC	I–III	FISH	Survival curves	≥4	NS
Russell et al. [31]	2014	Australia	352	50	14.2	NSCLC	I–IV	FISH	HR + CI	≥2.0	NS
Gadgeel et al. [22]	2013	America	345	12	3.5	NSCLC	I–IV	qPCR	HR + CI	>3.5	Poor
Craddock et al. [38]	2013	Canada	121	11	9.1	SQCC	I–IV	FISH	HR + CI	≥5	NS
Tran et al. [24]	2013	Australia	264	37	14.0	NSCLC	I–IV	CISH	Survival curves	≥2.0	Favor
Kim et al. [25]	2013	Korean	262	34	13.0	SQCC	I–III	FISH	HR + CI	≥9	Poor
Heist et al. [40]	2012	America	226	37	16.4	SQCC	I–IV	FISH	Survival curves	≥2.2	NS
Kohler et al. [28]	2012	Germany	133	14	10.5	SQCC	—	FISH	Survival curves	≥4	NS
Sasaki et al. [23]	2012	Japan	100	32	32.0	NSCLC	I–IV	qPCR	Survival curves	>4	NS
Weiss et al. [27]	2010	Germany	232	16	6.9	NSCLC	I–III	FISH	Survival curves	>9	NS

NP, number of patients; HR, hazard ratio; CI, confidence interval; NSCLC, non-small cell lung cancer; SQCC, squamous cell lung cancer; FISH, fluorescence in situ hybridization; qPCR, quantitative polymerase chain reaction; CISH, chromogenic in situ hybridization; NS, nonsignificant.