Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common Tissue

Figure 5

Common-motif, common-family, and common-tissue TF pair. HNF4A and NR1I3 are a pair of TFs with a common motif, common family (steroid hormone receptors), and common tissue (liver). (a) Jaccard coefficient at the subpathway level of HNF4A and NR1I3 was 0.1538. (b) Jaccard coefficient at the pathway level was 0.3333. (c) Jaccard coefficient at the pathway class level was 0.3333. (d) HNF4A regulated subpathway 00982-10, and NR1I3 regulated subpathway 00982-4. Red genes represent the shared genes between subpathways 00982-10 and 00982-4. Pink genes represent the genes only in subpathway 00982-4. Purple nodes represent the genes in the entire pathway 00982.