Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation

Figure 2

Low concentration of SB203580 abolished the PEDF-induced p38/MAPK phosphorylation. Representative blots and data summary of phospho-p38 (p-p38) and p38 in HUVECs under PEDF (200 ng/mL), SB203580 (5 μmol/mL), and PEDF (200 ng/mL) + SB203580 (5/10/15 μmol/mL) treatment at 6 h. Representative western blots are shown. Graph represents the mean ± SD ( in each group) of the relative integrated signals. , .

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