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BioMed Research International
Volume 2015 (2015), Article ID 791926, 7 pages
http://dx.doi.org/10.1155/2015/791926
Research Article

Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction

1Department of Laboratory Medicine, College of Medicine, Inha University, Incheon 22332, Republic of Korea
2School of Medicine, University of Tsukuba, Ibaraki, Japan
3Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan

Received 26 June 2015; Revised 18 August 2015; Accepted 26 August 2015

Academic Editor: Hai-Feng Pan

Copyright © 2015 Jong Weon Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Chakraborty, S. Kaur, S. Guha, and S. K. Batra, “The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer,” Biochimica et Biophysica Acta—Reviews on Cancer, vol. 1826, no. 1, pp. 129–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Singer, L. Markó, N. Paragas et al., “Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications,” Acta Physiologica, vol. 207, no. 4, pp. 663–672, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Giasson, G. H. Li, and Y. Chen, “Neutrophil gelatinase-associated lipocalin (NGAL) as a new biomarker for non-acute kidney injury (AKI) diseases,” Inflammation and Allergy—Drug Targets, vol. 10, no. 4, pp. 272–282, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Finlay, B. Bray, A. J. Lewington et al., “Identification of risk factors associated with acute kidney injury in patients admitted to acute medical units,” Clinical Medicine, vol. 13, no. 3, pp. 233–238, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. P. N. Cunningham, H. M. Dyanov, P. Park, J. Wang, K. A. Newell, and R. J. Quigg, “Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney,” Journal of Immunology, vol. 168, no. 11, pp. 5817–5823, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Lerolle, D. Nochy, E. Guérot et al., “Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration,” Intensive Care Medicine, vol. 36, no. 3, pp. 471–478, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Clerico, C. Galli, A. Fortunato, and C. Ronco, “Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences,” Clinical Chemistry and Laboratory Medicine, vol. 50, no. 9, pp. 1505–1517, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Haase, R. Bellomo, P. Devarajan et al., “Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis,” American Journal of Kidney Diseases, vol. 54, no. 6, pp. 1012–1024, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Aydoğdu, G. Gürsel, B. Sancak et al., “The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and cystatin C in early diagnosis of septic acute kidney injury in critically ill patients,” Disease Markers, vol. 34, no. 4, pp. 237–246, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation: Modification of Diet in Renal Disease Study Group,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Lindberg, J. S. Jensen, R. Mogelvang et al., “Plasma neutrophil gelatinase-associated lipocalinin in the general population: association with inflammation and prognosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 9, pp. 2135–2142, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. U. U. Tamhane, S. Aneja, D. Montgomery, E.-K. Rogers, K. A. Eagle, and H. S. Gurm, “Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome,” American Journal of Cardiology, vol. 102, no. 6, pp. 653–657, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. F. T. Kos, C. Hocazade, M. Kos et al., “Assessment of prognostic value of neutrophil to lymphocyte ratio and prognostic nutritional index as a sytemic inflammatory marker in on-small cell lung cancer,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 9, pp. 3997–4002, 2015. View at Google Scholar
  14. K. Turkmen, I. Guney, F. H. Yerlikaya, and H. Z. Tonbul, “The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients,” Renal Failure, vol. 34, no. 2, pp. 155–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. U. Okyay, S. Inal, K. Öneç et al., “Neutrophil to lymphocyte ratio in evaluation of inflammation in patients with chronic kidney disease,” Renal Failure, vol. 35, no. 1, pp. 29–36, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Wang, K. S. L. Lam, E. W. Kraegen et al., “Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans,” Clinical Chemistry, vol. 53, no. 1, pp. 34–41, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Y. Xu, K. Pauksen, and P. Venge, “Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 55, no. 2, pp. 125–131, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Smertka, J. Wroblewska, A. Suchojad et al., “Serum and urinary NGAL in septic newborns,” BioMed Research International, vol. 2014, Article ID 717318, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Xu, P. Sjogren, J. Arnlov et al., “A proinflammatory diet is associated with systemic inflammation and reduced kidney function in elderly adults,” Journal of Nutrition, vol. 145, no. 4, pp. 729–735, 2015. View at Publisher · View at Google Scholar
  20. J. Gupta, N. Mitra, P. A. Kanetsky et al., “Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC,” Clinical Journal of the American Society of Nephrology, vol. 7, no. 12, pp. 1938–1946, 2012. View at Publisher · View at Google Scholar · View at Scopus