Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction
Table 1
Baseline characteristics of subject population included in this study.
Patient populations ( = 162)
Healthy control ( = 45)
P value
Anthropometric parameters
Age (years)
63 (32–81)
62 (31–79)
0.704
Gender (male, %)
86 (53.1)
24 (53.3)
0.989
BMI (kg/m2)
22.5 ± 3.5
23.3 ± 2.6
0.361
Systolic BP (mmHg)
126.4 ± 27.1
129.8 ± 16.7
0.485
Lipocalin levels
NGAL (ng/mL)
186.5 (91.5–429.2)
60.0 (51.0–76.0)
<0.001
NGAL/sCr ratio
147.2 (81.5–261.2)
58.0 (51.0–76.0)
<0.001
Percent difference (95% CI)
9.1 (0.0–78.1)
0.0 (0.0–17.5)
<0.001
NGAL > 150 ng/mL (, %)
92 (56.8)
0 (0.0)
<0.001
Inflammation indices
hsCRP (mg/dL)
4.00 (1.93–11.23)
0.08 (0.04–0.16)
<0.001
hsCRP > 0.3 mg/dL (, %)
162 (100.0)
0 (0.0)
<0.001
cESR (mm/h)
25.0 (12.4–45.2)
4.3 (1.9–6.4)
<0.001
Neutrophil (×109/L)
6.57 (4.36–10.43)
4.09 (2.95–4.96)
<0.001
NLR
4.5 (3.0–12.1)
1.9 (1.2–3.1)
<0.001
Kidney function
eGFR (mL/min/1.73 m2)
67.8 (45.4–85.7)
86.2 (77.2–95.3)
<0.001
sCr (mg/dL)
1.10 (0.81–1.50)
0.89 (0.80–0.97)
<0.001
sCr 1.2 mg/dL (, %)
69 (42.6)
0 (0.0)
<0.001
BUN (mg/dL)
18.8 (12.1–28.8)
12.8 (10.7–15.5)
<0.001
Cardiac marker
CK-MB (ng/mL)
2.8 (1.2–6.7)
2.7 (1.2–3.7)
0.392
Troponin-I (ng/mL)
0.1 (0.1–0.3)
0.1 (0.1–0.3)
0.781
Data are expressed as mean ± SD, median (interquartile range), or frequency (%). BMI, body mass index; BP, blood pressure; NGAL, neutrophil gelatinase-associated lipocalin; NGAL/sCr ratio, NGAL-to-serum creatinine ratio; hsCRP, high sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; NLR, neutrophil-to-lymphocyte ratio; eGFR, estimated glomerular filtration rate; sCr, serum creatinine; CK-MB, creatine kinase-MB.
