BioMed Research International / 2015 / Article / Tab 1

Research Article

Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction

Table 1

Baseline characteristics of subject population included in this study.

Patient populations
( = 162)
Healthy control
( = 45)
P value

Anthropometric parameters
 Age (years)63 (32–81)62 (31–79)0.704
 Gender (male, %)86 (53.1)24 (53.3)0.989
 BMI (kg/m2)22.5 ± 3.523.3 ± 2.60.361
 Systolic BP (mmHg)126.4 ± 27.1129.8 ± 16.70.485
Lipocalin levels
 NGAL (ng/mL)186.5 (91.5–429.2)60.0 (51.0–76.0)<0.001
 NGAL/sCr ratio147.2 (81.5–261.2)58.0 (51.0–76.0)<0.001
 Percent difference (95% CI)9.1 (0.0–78.1)0.0 (0.0–17.5)<0.001
 NGAL > 150 ng/mL (, %)92 (56.8)0 (0.0)<0.001
Inflammation indices
 hsCRP (mg/dL)4.00 (1.93–11.23)0.08 (0.04–0.16)<0.001
 hsCRP > 0.3 mg/dL (, %)162 (100.0)0 (0.0)<0.001
 cESR (mm/h)25.0 (12.4–45.2)4.3 (1.9–6.4)<0.001
 Neutrophil (×109/L)6.57 (4.36–10.43)4.09 (2.95–4.96)<0.001
 NLR4.5 (3.0–12.1)1.9 (1.2–3.1)<0.001
Kidney function
 eGFR (mL/min/1.73 m2)67.8 (45.4–85.7)86.2 (77.2–95.3)<0.001
 sCr (mg/dL)1.10 (0.81–1.50)0.89 (0.80–0.97)<0.001
 sCr 1.2 mg/dL (, %)69 (42.6)0 (0.0)<0.001
 BUN (mg/dL)18.8 (12.1–28.8)12.8 (10.7–15.5)<0.001
Cardiac marker
 CK-MB (ng/mL)2.8 (1.2–6.7)2.7 (1.2–3.7)0.392
 Troponin-I (ng/mL)0.1 (0.1–0.3)0.1 (0.1–0.3)0.781

Data are expressed as mean ± SD, median (interquartile range), or frequency (%).
BMI, body mass index; BP, blood pressure; NGAL, neutrophil gelatinase-associated lipocalin; NGAL/sCr ratio, NGAL-to-serum creatinine ratio; hsCRP, high sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; NLR, neutrophil-to-lymphocyte ratio; eGFR, estimated glomerular filtration rate; sCr, serum creatinine; CK-MB, creatine kinase-MB.

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