BioMed Research International / 2015 / Article / Tab 2

Research Article

Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction

Table 2

Plasma NGAL levels and NGAL/sCr ratios in relation to kidney function in patients with inflammation.

Patients with inflammation value
Without renal impairment
(sCr < 1.2 mg/dL, = 93)
With renal impairment
(sCr ≥ 1.2 mg/dL, = 69)

Lipocalin levels
 NGAL (ng/mL)125.0 (76.0–208.0)417.0 (182.5–973.5)<0.001
 NGAL/sCr ratio121.0 (71.7–204.9)229.9 (100.2–320.3)<0.001
 Percent difference (95% CI)0.0 (0.0–14.1)36.7 (18.4–83.7)<0.001
 NGAL > 150 ng/mL (, %)37 (39.8)55 (79.7)<0.001
Inflammation indices
 hsCRP (mg/dL)3.24 (0.98–8.41)6.17 (3.21–14.76)<0.001
 cESR (mm/h)20.9 (9.7–36.5)32.8 (15.2–54.2)0.004
 Neutrophil (×109/L)6.17 (4.23–10.06)7.05 (4.92–11.37)0.095
 NLR3.8 (2.9–10.2)5.7 (3.1–12.7)0.037
Kidney function
 eGFR (mL/min/1.73 m2)82.4 (72.4–101.4)42.3 (23.3–53.7)<0.001
 sCr (mg/dL)0.83 (0.74–1.03)1.58 (1.31–2.55)<0.001
 BUN (mg/dL)13.7 (10.9–19.4)30.8 (20.5–49.7)<0.001

Data are expressed as median (interquartile range) or frequency (%).
NGAL, neutrophil gelatinase-associated lipocalin; NGAL/sCr ratio, NGAL-to-serum creatinine ratio; hsCRP, high sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; NLR, neutrophil-to-lymphocyte ratio; eGFR, estimated glomerular filtration rate; sCr, serum creatinine; BUN, blood urea nitrogen.

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