Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction
Table 2
Plasma NGAL levels and NGAL/sCr ratios in relation to kidney function in patients with inflammation.
Patients with inflammation
value
Without renal impairment (sCr < 1.2 mg/dL, = 93)
With renal impairment (sCr ≥ 1.2 mg/dL, = 69)
Lipocalin levels
NGAL (ng/mL)
125.0 (76.0–208.0)
417.0 (182.5–973.5)
<0.001
NGAL/sCr ratio
121.0 (71.7–204.9)
229.9 (100.2–320.3)
<0.001
Percent difference (95% CI)
0.0 (0.0–14.1)
36.7 (18.4–83.7)
<0.001
NGAL > 150 ng/mL (, %)
37 (39.8)
55 (79.7)
<0.001
Inflammation indices
hsCRP (mg/dL)
3.24 (0.98–8.41)
6.17 (3.21–14.76)
<0.001
cESR (mm/h)
20.9 (9.7–36.5)
32.8 (15.2–54.2)
0.004
Neutrophil (×109/L)
6.17 (4.23–10.06)
7.05 (4.92–11.37)
0.095
NLR
3.8 (2.9–10.2)
5.7 (3.1–12.7)
0.037
Kidney function
eGFR (mL/min/1.73 m2)
82.4 (72.4–101.4)
42.3 (23.3–53.7)
<0.001
sCr (mg/dL)
0.83 (0.74–1.03)
1.58 (1.31–2.55)
<0.001
BUN (mg/dL)
13.7 (10.9–19.4)
30.8 (20.5–49.7)
<0.001
Data are expressed as median (interquartile range) or frequency (%). NGAL, neutrophil gelatinase-associated lipocalin; NGAL/sCr ratio, NGAL-to-serum creatinine ratio; hsCRP, high sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; NLR, neutrophil-to-lymphocyte ratio; eGFR, estimated glomerular filtration rate; sCr, serum creatinine; BUN, blood urea nitrogen.
