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BioMed Research International
Volume 2015, Article ID 794862, 10 pages
http://dx.doi.org/10.1155/2015/794862
Research Article

Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF-β1/Smad Signaling

1Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 210029, China
2Model Animal Research Center of Nanjing University, Nanjing, Jiangsu 210061, China

Received 1 September 2014; Revised 18 November 2014; Accepted 18 November 2014

Academic Editor: Yury Popov

Copyright © 2015 Na Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Shi-zhang Wei, Sheng-qiang Luo, Jian Wang, Jia-bo Wang, Rui-sheng Li, Xiao-mei Zhang, Yan-lei Guo, Chang Chen, Xiao Ma, Zhe Chen, Hong-hong Liu, Zhi-rui Yang, Jian-yu Li, Rui-lin Wang, Ya-ming Zhang, Hui-yin Yang, Xiao-he Xiao, and Yan-ling Zhao, “San-Cao Granule (三草颗粒) ameliorates hepatic fibrosis through high mobility group box-1 protein/smad signaling pathway,” Chinese Journal of Integrative Medicine, 2015. View at Publisher · View at Google Scholar
  • Raúl Vivar, Claudio Humeres, Claudia Muñoz, Pía Boza, Samir Bolivar, Felipe Tapia, Sergio Lavandero, Mario Chiong, and Guillermo Diaz-Araya, “FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015. View at Publisher · View at Google Scholar
  • Kai Chen, Ya-Mei Rong, Wei-Li Cao, Lin-Fei Zong, and Run-Li Ji, “Effect of oxymatrine on expression of molecules of Smad signal pathway in pancreatic stellate cells stimulated with TGF-β1,” World Chinese Journal of Digestology, vol. 23, no. 12, pp. 1883–1889, 2015. View at Publisher · View at Google Scholar
  • Pierre Theurey, and Jennifer Rieusset, “Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases,” Trends in Endocrinology & Metabolism, 2016. View at Publisher · View at Google Scholar
  • An Tang, Anying Song, Dayuan Zou, Yue Zhou, Pengyu Gu, Zan Huang, Qinghua Wang, Xiang Gao, Peiliang Shi, and Zhaoyu Lin, “PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte,” Cell Cycle, vol. 15, no. 11, pp. 1450–1461, 2016. View at Publisher · View at Google Scholar
  • Sara Reynhout, and Veerle Janssens, “Physiologic functions of PP2A: Lessons from genetically modified mice,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018. View at Publisher · View at Google Scholar
  • Rathinasamy Baskaran, and Bharath Kumar Velmurugan, “Protein phosphatase 2A as therapeutic targets in various disease models,” Life Sciences, vol. 210, pp. 40–46, 2018. View at Publisher · View at Google Scholar
  • Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, and Xiaoxiao Yang, “Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner,” Biochemical and Biophysical Research Communications, 2019. View at Publisher · View at Google Scholar