BioMed Research International / 2015 / Article / Tab 4

Review Article

Comparison of Fine Needle Aspiration and Fine Needle Nonaspiration Cytology of Thyroid Nodules: A Meta-Analysis

Table 4

Analysis of the results.

Results Number of studies Sample size
FNAC/FNNAC
Overall effect size95% CI valueHeterogeneity

Unsuitable for diagnosis12 [8, 1014, 20, 2327]1912/1912OR = 1.09(0.91, 1.30)0.3640%0.07
Diagnostically superior11 [8, 1014, 2327]1844/1844OR = 0.81(0.60, 1.09)0.1673%<0.0001
Background blood or clot5 [8, 10, 13, 24, 28]986/986MD = −0.41(−0.84, 0.02)0.0698%<0.0001
Degree of cellular trauma5 [8, 10, 13, 24, 28]986/986MD = 0.06(−0.14, 0.26)0.5690%<0.00001
Amount of cellular material5 [8, 10, 13, 24, 28]986/986MD = −0.11(−0.35, 0.13)0.3592%<0.00001
Degree of cellular degeneration5 [8, 10, 13, 24, 28]986/986MD = 0.05(−0.10, 0.21)0.5181%0.0003
Retention of appropriate architecture5 [8, 10, 13, 24, 28]986/986MD = −0.27(−0.69, 0.15)0.2197%<0.00001
Total score of five parameters5 [8, 10, 13, 14, 24] 1172/1172MD = −0.36(−1.03, 0.30)0.2990%<0.00001
Accuracy5 [10, 15, 1921]182/192OR = 0.96(0.56, 1.65)0.8912%0.34
Sensitivity4 [10, 15, 19, 21]146/154OR = 1.35(0.35, 5.19)0.660%0.74
Specificity4 [10, 15, 19, 21]146/154OR = 1.13(0.56, 2.29)0.7320%0.26
Negative predictive value (NPV)4 [10, 15, 19, 21]146/154OR = 1.20(0.35, 4.11)0.780%0.78
Positive predictive value (PPV)4 [10, 15, 19, 21]146/154OR = 1.17(0.50, 2.76)0.710%0.46

OR: odds ratios, MD: mean difference.