Review Article
Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View
Figure 4
Characteristics of heterocellular interaction between myofibroblasts and cardiomyocytes in regionally infarcted rat heart. (a) Top. Immunohistochemistry picture of rat heart slices after 37 weeks of coronary occlusion. A region of myofibroblasts (brown) stained for αSMA physically separates two bundles of cardiac myocytes. Bottom. Schematic representation of heterocellular culture mimics the in vivo situation. (b) Same as A with a MFBs stratum infiltrated into cardiac tissue (top) with schematic represented situation (bottom) (with courtesy: Dr. Alex Lyon, NHLI, Imperial College, London. Unpublished).
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