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BioMed Research International
Volume 2015, Article ID 804731, 8 pages
http://dx.doi.org/10.1155/2015/804731
Research Article

Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu

1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China
2Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, 2 Zizhulin, Nanjing, Jiangsu 210009, China
3Department of Chronic Non-Communicable Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China

Received 26 August 2014; Revised 7 December 2014; Accepted 11 December 2014

Academic Editor: Cheng-Feng Qin

Copyright © 2015 Pingmin Wei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Li, L. Zhou, M. Zhou et al., “Epidemiology of human infections with avian influenza A(H7N9) virus in China,” The New England Journal of Medicine, vol. 370, no. 6, pp. 520–532, 2014. View at Publisher · View at Google Scholar · View at PubMed
  2. M. K. Cheung, “Human infection with H7N9 virus,” The New England Journal of Medicine, vol. 369, no. 9, pp. 879–880, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. T. M. Uyeki and N. J. Cox, “Global concerns regarding novel influenza a (H7N9) virus infections,” The New England Journal of Medicine, vol. 368, no. 20, pp. 1862–1864, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. W. Chen, P. A. Calvo, D. Malide et al., “A novel influenza A virus mitochondrial protein that induces cell death,” Nature Medicine, vol. 7, no. 12, pp. 1306–1312, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. K. Bruns, N. Studtrucker, A. Sharma et al., “Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein,” Journal of Biological Chemistry, vol. 282, no. 1, pp. 353–363, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. D. Zamarin, A. García-Sastre, X. Xiao, R. Wang, and P. Palese, “Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1,” PLoS Pathogens, vol. 1, no. 1, article e4, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. A. P. Halestrap and C. Brenner, “The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death,” Current Medicinal Chemistry, vol. 10, no. 16, pp. 1507–1525, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Vyssokikh and D. Brdiczka, “VDAC and peripheral channelling complexes in health and disease,” Molecular and Cellular Biochemistry, vol. 256-257, no. 1-2, pp. 117–126, 2004. View at Google Scholar · View at Scopus
  9. S. Shimizu, M. Narita, and Y. Tsujimoto, “Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC,” Nature, vol. 399, no. 6735, pp. 483–487, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. I. Mazur, D. Anhlan, D. Mitzner, L. Wixler, U. Schubert, and S. Ludwig, “The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein,” Cellular Microbiology, vol. 10, no. 5, pp. 1140–1152, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. I. Košík, I. Krejnusová, M. Bystrická, K. Poláková, and G. Russ, “N-terminal region of the PB1-F2 protein is responsible for increased expression of influenza A viral protein PB1,” Acta Virologica, vol. 55, no. 1, pp. 45–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. L. Mcauley, J. E. Chipuk, K. L. Boyd, N. van de Velde, D. R. Green, and A. M. Jonathan, “PB1-F2 proteins from H5N1 and 20th century pandemic influenza viruses cause immunopathology,” PLoS Pathogens, vol. 6, no. 7, Article ID e1001014, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. D. Mitzner, S. E. Dudek, N. Studtrucker et al., “Phosphorylation of the influenza a virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes,” Cellular Microbiology, vol. 11, no. 10, pp. 1502–1516, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. G. A. Bergen, S. G. Gompf, P. A. Sakalosky, and J. T. Sinnott, “Influenza. More than mom and chicken soup,” The Journal of the Florida Medical Association, vol. 83, no. 1, pp. 19–22, 1996. View at Google Scholar · View at Scopus
  15. J. R. Coleman, “The PB1-F2 protein of Influenza A virus: increasing pathogenicity by disrupting alveolar macrophages,” Virology Journal, vol. 4, article 9, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. Y. Sibille and H. Y. Reynolds, “Macrophages and polymorphonuclear neutrophils in lung defense and injury,” The American Review of Respiratory Disease, vol. 141, no. 2 I, pp. 471–501, 1990. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. L. Pond, S. D. W. Frost, and S. V. Muse, “HyPhy: hypothesis testing using phylogenies,” Bioinformatics, vol. 21, no. 5, pp. 676–679, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. I. Khandaker, A. Suzuki, T. Kamigaki et al., “Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009–2011,” Virus Genes, vol. 47, no. 3, pp. 456–466, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. X. Qi, Y.-H. Qian, C.-J. Bao et al., “Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation,” British Medical Journal, vol. 347, Article ID f4752, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. H. Yu, J. T. Wu, B. J. Cowling et al., “Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study,” The Lancet, vol. 383, no. 9916, pp. 541–548, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. Smith and J. A. McCullers, “Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses,” Virus Research, vol. 178, no. 1, pp. 146–150, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. I. V. Alymova, A. M. Green, N. van de Velde et al., “Immunopathogenic and antibacterial effects of H3N2 influenza a virus PB1-F2 map to amino acid residues 62, 75, 79, and 82,” Journal of Virology, vol. 85, no. 23, pp. 12324–12333, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. L. Q. Fang, X. L. Li, K. Liu et al., “Mapping spread and risk of avian influenza A (H7N9) in China,” Scientific Reports, vol. 3, article 2722, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. R. Arunachalam, “Adaptive evolution of a novel avian-origin inuenza A/H7N9 virus,” Genomics, vol. 104, no. 6, part B, pp. 545–553, 2014. View at Publisher · View at Google Scholar · View at PubMed
  25. Y. Furuse, K. Shimabukuro, T. Odagiri et al., “Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses,” Virology, vol. 405, no. 2, pp. 314–321, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. A. K. Chakrabarti and G. Pasricha, “An insight into the PB1F2 protein and its multifunctional role in enhancing the pathogenicity of the influenza A viruses,” Virology, vol. 440, no. 2, pp. 97–104, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. W. W. Thompson, D. K. Shay, E. Weintraub et al., “Mortality associated with influenza and respiratory syncytial virus in the United States,” Journal of the American Medical Association, vol. 289, no. 2, pp. 179–186, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. W. W. Thompson, D. K. Shay, E. Weintraub et al., “Influenza-associated hospitalizations in the United States,” Journal of the American Medical Association, vol. 292, no. 11, pp. 1333–1340, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. L. Simonsen, K. Fukuda, L. B. Schonberger, and N. J. Cox, “The impact of influenza epidemics on hospitalizations,” Journal of Infectious Diseases, vol. 181, no. 3, pp. 831–837, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. H. Yamada, R. Chounan, Y. Higashi, N. Kurihara, and H. Kido, “Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria,” FEBS Letters, vol. 578, no. 3, pp. 331–336, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. J. S. Gibbs, D. Malide, F. Hornung, J. R. Bennink, and J. W. Yewdell, “The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function,” Journal of Virology, vol. 77, no. 13, pp. 7214–7224, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. G. M. Conenello, D. Zamarin, L. A. Perrone, T. Tumpey, and P. Palese, “A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence,” PLoS Pathogens, vol. 3, no. 10, pp. 1414–1421, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. Z. T. Varga, I. Ramos, R. Hai et al., “The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein,” PLoS Pathogens, vol. 7, no. 6, Article ID e1002067, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. G. M. Conenello, J. R. Tisoncik, E. Rosenzweig, Z. T. Varga, P. Palese, and M. G. Katze, “A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo,” Journal of Virology, vol. 85, no. 2, pp. 652–662, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus