A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer’s Disease

Figure 3

Comparative analysis of Aβ plaque burden in the brains of APP/PS1 mice. Mean of Aβ plaque burden in the hippocampal and cortical regions of APPswe/PS1ΔE9 mice in the five treatment groups. The mean of the Aβ burden is significantly reduced () in Group A (EB101) when compared with Groups B–E during preventive treatment and markedly reduced in the therapeutic treatment period. Data are presented as mean ± standard error of the mean (SEM). Density mean of Aβ plaques in Tg mice hippocampus.