The Impact of Vitamin D₃ Supplementation on Mechanisms of Cell Calcium Signaling in Chronic Kidney Disease

Figure 4

The effect of vitamin D₃ supplementation on activation by BzATP. (a) The comparison of the BzATP (50 μmol/L) effect on [Ca²⁺]_i in CKD patients at baseline and after vitamin D₃ supplementation (, ). (b) A typical experiment where PBMCs were pretreated with AZ11645373 (50 nmol/L) prior to the application of BzATP (50 μmol/L). (c) The comparison of the BzATP (50 μmol/L) effect on AZ11645373 (50 nmol/L)-inhibited calcium influx in PBMCs before and after supplementation (, ).

(a)  

(b)

(c)