BioMed Research International / 2015 / Article / Fig 1

Research Article

Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma

Figure 1

Immunoprofiles of p53, Ki67, ALDH1, CD44, and CD117 in normal-appearing fallopian tube, STIC, AOC (associated carcinoma with STICs), and non-AOC (carcinoma without STICs). STICs are defined by an intense and diffuse expression of TP53 with a moderate to high Ki67 proliferative index. Expression of TP53 and Ki67 is absent in benign-appearing fallopian tubes whereas it is intense and higher in AOC and non-AOC. ALDH1A and CD117 staining is detected in both secretory and ciliated cells of the benign-appearing fallopian tubes. The level of ALDH1 expression is significantly lower in STICs, AOC, and non-AOC than in normal fallopian tube. CD117 expression level is as high as in benign tube and AOC but significantly lower in non-AOC. There is also an increase in the CD117 positive cells in the STICs compared to fallopian tube epithelium. The expression level of CD44 was weak or absent in most specimens. However, expression is significantly lower in non-AOC than in benign tubes, STICs, and AOC.