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BioMed Research International
Volume 2015, Article ID 809714, 7 pages
http://dx.doi.org/10.1155/2015/809714
Clinical Study

A Phase I Trial to Evaluate the Multiple-Dose Safety and Antitumor Activity of Ursolic Acid Liposomes in Subjects with Advanced Solid Tumors

Department of Lymphoma, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Huanhuxi Road, Hexi District, Tianjin 300060, China

Received 25 June 2014; Revised 9 October 2014; Accepted 12 October 2014

Academic Editor: Shiwu Zhang

Copyright © 2015 Zhengzi Qian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [24 citations]

The following is the list of published articles that have cited the current article.

  • Lukasz Wozniak, Sylwia Skapska, and Krystian Marszalek, “Ursolic Acid-A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities,” Molecules, vol. 20, no. 11, pp. 20614–20641, 2015. View at Publisher · View at Google Scholar
  • Anna M. Mancha-Ramirez, and Thomas J. Slaga, “Ursolic Acid and Chronic Disease: An Overview of UA’s Effects On Prevention and Treatment of Obesity and Cancer,” Anti-inflammatory Nutraceuticals and Chronic Diseases, vol. 928, pp. 75–96, 2016. View at Publisher · View at Google Scholar
  • Qixiao Jiang, Yantao Han, Hui Gao, Rong Tian, Ping Li, and Chunbo Wang, “Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K,” European Journal of Pharmacology, 2016. View at Publisher · View at Google Scholar
  • Filomena S. G. Silva, Paulo J. Oliveira, and Maria F. Duarte, “Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?,” Journal of Agricultural and Food Chemistry, 2016. View at Publisher · View at Google Scholar
  • Qiuxia Huang, Hongfei Chen, Xuan Li, Juan Wang, Xing Zheng, Yuyan Ren, Zhe Wang, and Peiyu Zeng, “Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives,” Pharmaceutical Biology, vol. 54, no. 12, pp. 3189–3196, 2016. View at Publisher · View at Google Scholar
  • Jiaxin Pi, Zhidong Liu, Zhuangzhi Zhu, Hao Wang, Xing Gu, Shuya Wang, Bing Zhang, and Hansen Luan, “Ursolic acid nanocrystals for dissolution rate and bioavailability enhancement: Lnfluence of different particle size,” Current Drug Delivery, vol. 13, no. 8, pp. 1358–1366, 2016. View at Publisher · View at Google Scholar
  • Karina Valdés, Javier Morales, Lennin Rodríguez, and Germán Günther, “Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments,” Nanomedicine, vol. 12, no. 23, pp. 3139–3156, 2016. View at Publisher · View at Google Scholar
  • Yanzhe Wang, Zhiyi He, and Shumin Deng, “Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury,” Drug Design Development And Therapy, vol. 10, 2016. View at Publisher · View at Google Scholar
  • Ivan R. Green, Iftikhar Ali, Ikhlas A. Khan, Zulfiqar Ali, Abdullah M. Al-Sadi, Ishtiaq Ahmed, and Hidayat Hussain, “Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016),” Expert Opinion on Therapeutic Patents, vol. 27, no. 9, pp. 1061–1072, 2017. View at Publisher · View at Google Scholar
  • Hong Wang, Meng-Kwoon Sim, Weng Keong Loke, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Feng Ru Tang, and Gautam Sethi, “Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced Damage Are Mediated through the Modulation of Diverse Inflammatory Mediators,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • James Z. Shen, Ting L. J. Ng, and Wing S. Ho, “Therapeutic potential of phytochemicals in combination with drugs for cardiovascular disorders,” Current Pharmaceutical Design, vol. 23, no. 6, pp. 961–966, 2017. View at Publisher · View at Google Scholar
  • Mohamed A. Hamzawy, Amira M. Abo-youssef, Heba F. Salem, and Sameh A. Mohammed, “Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice,” Drug Delivery, vol. 24, no. 1, pp. 599–607, 2017. View at Publisher · View at Google Scholar
  • Lucy Catteau, Nathalie Reichmann, Joshua Olson, Mariana Pinho, Victor Nizet, Françoise Van Bambeke, and Joëlle Quetin-Leclercq, “Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms,” Molecules, vol. 22, no. 12, pp. 2245, 2017. View at Publisher · View at Google Scholar
  • Ana B. Ramos-Hryb, Francis L. Pazini, Manuella P. Kaster, and Ana Lúcia S. Rodrigues, “Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases,” CNS Drugs, 2017. View at Publisher · View at Google Scholar
  • Chengyue Zhang, Chao Wang, Wenji Li, Renyi Wu, Yue Guo, David Cheng, Yuqing Yang, Ioannis P. Androulakis, and Ah-Ng Kong, “Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes,” Molecular Pharmaceutics, 2017. View at Publisher · View at Google Scholar
  • Ana B. Ramos-Hryb, Mauricio P. Cunha, Manuella P. Kaster, and Ana Lúcia S. Rodrigues, “Natural Polyphenols and Terpenoids for Depression Treatment: Current Status,” vol. 55, pp. 181–221, 2017. View at Publisher · View at Google Scholar
  • Yanzhe Wang, Lei Li, Shumin Deng, Fang Liu, and Zhiyi He, “Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway,” Frontiers in Neurology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Y. Yoshimasu, T. Ikeda, N. Sakai, A. Yagi, S. Hirayama, Y. Morinaga, S. Furukawa, and R. Nakao, “ Rapid Bactericidal Action of Propolis against Porphyromonas gingivalis ,” Journal of Dental Research, pp. 002203451875803, 2018. View at Publisher · View at Google Scholar
  • Javed Iqbal, Banzeer Ahsan Abbasi, Riaz Ahmad, Tariq Mahmood, Sobia Kanwal, Barkat Ali, Ali Talha Khalil, Sayed Afzal Shah, Muhammad Maqsood Alam, and Hussain Badshah, “Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications,” Biomedicine & Pharmacotherapy, vol. 108, pp. 752–756, 2018. View at Publisher · View at Google Scholar
  • Stefanie Staats, Anika E. Wagner, Kai Lüersen, Axel Künstner, Timo Meyer, Anna K. Kahns, Stefanie Derer, Simon Graspeuntner, Jan Rupp, Hauke Busch, Christian Sina, Ignacio R. Ipharraguerre, and Gerald Rimbach, “ Dietary ursolic acid improves health span and life span in male Drosophila melanogaster ,” BioFactors, 2018. View at Publisher · View at Google Scholar
  • Lisa Tremmel, Okkyung Rho, Thomas J. Slaga, and John DiGiovanni, “Inhibition of skin tumor promotion by TPA using a combination of topically applied ursolic acid and curcumin,” Molecular Carcinogenesis, 2018. View at Publisher · View at Google Scholar
  • Jianhai Yin, Congshan Liu, Yujuan Shen, Haobing Zhang, and Jianping Cao, “Efficacy of ursolic acid against Echinococcus granulosus in vitro and in a murine infection model,” Parasites & Vectors, vol. 11, no. 1, 2018. View at Publisher · View at Google Scholar
  • Shadi Gharibi, Nuredin Bakhtiari, Elham-Moslemee-Jalalvand, and Fatemeh Bakhtiari, “Ursolic acid mediates hepatic protection through enhancing of anti-aging biomarkers,” Current Aging Science, vol. 11, no. 1, pp. 16–23, 2018. View at Publisher · View at Google Scholar
  • Sahdeo Prasad, Amit K. Tyagi, and Bharat Bhushan Aggarwal, “Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy,” Role of Nutraceuticals in Chemoresistance to Cancer, pp. 99–109, 2018. View at Publisher · View at Google Scholar