Vitamin D Receptor Gene Polymorphisms and Haplotypes in Hungarian Patients with Idiopathic Inflammatory Myopathy

Table 2

Distribution of VDR-FokI, VDR-BsmI, VDR-TaqI, and VDR-ApaI genotypes in our Hungarian cases and controls.

Enzyme analysis	IIM patients; (89 patients)	PM, JPM, IBM, NAM; (49 patients)	DM, JDM; (23 patients)	Overlap; (17 patients)	Controls; (93 person)
BsmI polymorphism
Genotypes
BB	19,1%	18,37%	8,69%	35,3%	15,9%
Bb	39,33%	36,73%	47,83%	35,3%	46,2%
bb	41,57%	44,9%	43,48%	29,4%	37,8%
Allele frequencies
B	0,387	0,367	0,326	0,529	0,39
b	0,612	0,633	0,674	0,471	0,61
ApaI polymorphism
Genotypes
AA	37,07%	34,69%	30,43%	52,94%	24,73%
Aa	39,33%	38,78%	52,17%	23,53%	50,54%
aa	23,6%	26,53%	17,4%	23,53%	24,73%
Allele frequencies
A	0,567	0,541	0,565	0,647	0,5
a	0,433	0,459	0,435	0,353	0,5
TaqI polymorphism
Genotypes
TT	43,82%	51,02%	34,78%	35,3%	40,86%
Tt	37,08%	28,57%	52,18%	41,17%	39,79%
tt	19,1%	20,41%	13,04%	23,53%	19,35%
Allele frequencies
T	0,623	0,653	0,609	0,559	0,61
t	0,376	0,347	0,391	0,441	0,39
FokI polymorphism
Genotypes
FF	26,97%	30,61%	21,74%	23,53%	42,25%
Ff	48,31%	42,86%	52,17%	58,82%	43,66%
ff	24,72%	26,53%	26,09%	17,65%	14,08%
Allele frequencies
F	0,511	0,52	0,478	0,529	0,64
f	0,489	0,48	0,522	0,471	0,36