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BioMed Research International
Volume 2015, Article ID 812027, 5 pages
http://dx.doi.org/10.1155/2015/812027
Research Article

Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence

1Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
2IDIVAL, 39011 Santander, Spain
3Ginecología y Obstetricia, Hospital Universitario de Puerto Real, 11510 Puerto Real, Spain
4Oncología Médica, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
5Radiodiagnóstico, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
6Anatomía Patológica, Hospital Universitario de Puerto Real, 11510 Puerto Real, Spain
7Anatomía Patológica, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
8Gerencia Atención Primaria, Servicio Cántabro de Salud, 39011 Santander, Spain

Received 14 January 2015; Accepted 17 February 2015

Academic Editor: Konstantinos Arnaoutakis

Copyright © 2015 Javier Freire et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite the progress achieved in the treatment of breast cancer, there are still many unsolved clinical issues, being the diagnosis, prognosis, and treatment of papillary diseases, one of the highest challenges. Because of its unpredictable clinical behavior, treatment of intraductal papilloma has generated a great controversy. Even though considered as a benign lesion, it presents high rate of malignant recurrence. This is the reason why there are clinicians supporting a complete excision of the lesion, while others support an only expectant follow-up. Previous results of our group suggested that procollagen 11 alpha 1 (pro-COL11A1) expression correlates with infiltrating phenotype in breast lesions. We analyzed the correlation between expression of pro-COL11A1 in intraductal papilloma and their risk of malignant recurrence. Immunohistochemistry of pro-COL11A1 was performed in 62 samples of intraductal papilloma. Ten out 11 cases relapsed as carcinoma presents positive staining for COL11A1, while just 17 out of 51 cases with benign behaviour present immunostaining. There were significant differences () when comparing patients with malignant recurrence versus nonmalignant relapse patients. These data suggest that pro-COL11A1 expression is a highly sensitive biomarker to predict malignant relapse of intraductal papilloma and it can be used as indicative factor for prevention programs.