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BioMed Research International
Volume 2015, Article ID 812027, 5 pages
http://dx.doi.org/10.1155/2015/812027
Research Article

Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence

1Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
2IDIVAL, 39011 Santander, Spain
3Ginecología y Obstetricia, Hospital Universitario de Puerto Real, 11510 Puerto Real, Spain
4Oncología Médica, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
5Radiodiagnóstico, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
6Anatomía Patológica, Hospital Universitario de Puerto Real, 11510 Puerto Real, Spain
7Anatomía Patológica, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
8Gerencia Atención Primaria, Servicio Cántabro de Salud, 39011 Santander, Spain

Received 14 January 2015; Accepted 17 February 2015

Academic Editor: Konstantinos Arnaoutakis

Copyright © 2015 Javier Freire et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

SD Figure1: Kaplan-Meier recurrence free analysis across categories of COL11A1. Cox regression analysis presents highly statistical significance (P=0.0008) while comparing positive and negative staining, with a HR of malignant recurrence of 12.6 (3.8–41.4) when positive immunostaining for proCOL11A1 appears in the core-needle biopsy of Intraductal Papilloma.

  1. Supplementary Materials