Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier

Figure 5

Comparison of concentration of bulk piracetam (a) and Si-piracetam (b) in brain tissue samples: this chromatogram presents very low concentration of drug, close to limit of quantification (S/N close 20/1). Found ratio of piracetam/Si-piracetam is approximately 20 : 1.

(a)

(b)